Impact of the Arterial Input Function Recording Method on Kinetic Parameters in Small-Animal PET

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Hanna NapieczynskaBernd J Pichler

Abstract

The goal of this study was to validate the use of an MR-compatible blood sampler (BS) with a detector system based on a lutetium oxyorthosilicate scintillator and avalanche photodiodes for small-animal PET. Methods: Five rats underwent a 60-min 18F-FDG study. For each animal, the arterial input function (AIF) was derived from the BS recording, from manual sampling (MS), and from the PET image. These AIFs were applied for kinetic modeling of the striatum using the irreversible 2-tissue-compartment model. The MS-based technique with a dispersion correction served as a reference approach, and the kinetic parameters that were estimated with the BS- and the image-derived AIFs were compared with the reference values. Additionally, the effect of applying a population-based activity ratio for plasma to whole blood (p/wb) and the dispersion correction was assessed. Results: The K1, k2, and k3 values estimated with the reference approach were 0.174 ± 0.037 mL/min/cm3, 0.342 ± 0.080 1/min, and 0.048 ± 0.009 1/min, respectively. The corresponding parameters obtained with the BS- and image-derived AIFs deviated from these values by 0.6%-18.8% and 16.7%-47.9%, respectively. To compensate for the error in the BS-based technique, data from one...Continue Reading

References

Oct 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H IidaK Uemura
May 11, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Bruno WeberAlfred Buck
Dec 10, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Bruno WeberAlfred Buck
Mar 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Yu-Hua Dean Fang, Raymond F Muzic
Sep 17, 2010·Physics in Medicine and Biology·J BreuerK Wienhard
Nov 20, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Malte F AlfStefanie D Krämer
May 17, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Hans F WehrlBernd J Pichler
Mar 26, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Yongfeng YangSimon R Cherry
Apr 1, 2017·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Julia G MannheimBernd J Pichler
Apr 20, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Geoffrey WarnockCristina Rossi

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Citations

Jun 7, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Kristina HerfertBernd J Pichler
Nov 18, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·David Rey-BretalPablo Aguiar

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