Oct 26, 2013

Impact of the baseline anti-A/B antibody titer on the clinical outcome in ABO-incompatible kidney transplantation

Nephron. Clinical Practice
Byung Ha ChungChul Woo Yang

Abstract

We investigated the impact of the baseline anti-A/B antibody titer on the clinical outcome in ABO-incompatible kidney transplantation (IKT). We included 183 patients who had undergone KT (40 ABO IKT and 143 ABO-compatible KT). Eight patients with a baseline titer of ≥1:512 were assigned to the high-titer group and 32 patients with a baseline titer of ≤1:256 were assigned to the low-titer group. Patients who underwent ABO-compatible KT were used as the control group. We compared the clinical outcomes of the three groups. Before transplantation, the high-titer group displayed more frequent antibody rebound, as shown in a lower titer reduction rate, and more difficulty reaching the target titer (1:16) than the low-titer group. During the postoperative period and out-clinic follow-up, antibody rebound was more frequent, and the rate of acute rejection and infection were significantly higher and allograft function was lower in the high-titer group than in the low-titer and control groups. Multivariate analysis showed that high baseline antibody titer was an independent risk factor for acute rejection. ABO IKT in the high-titer group (baseline titer ≥1:512) required greater caution compared to the low-titer group because of the highe...Continue Reading

  • References36
  • Citations11

References

  • References36
  • Citations11

Citations

Mentioned in this Paper

T-Lymphocyte
Virus Diseases
Peripheral Blood
Blood Group H Type 1 Antigen
Mycophenolate mofetil
Reinforcing Factors
Antibody Titer Measurement
Transplantation Immunology
Transcription Initiation
Isoantibodies

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