Impact of the cardiac arrest mode on cardiac death donor lungs

The Journal of Surgical Research
Tetsu YamadaHiroshi Date

Abstract

Donation after cardiac death (DCD) organs could alleviate the shortage of donor lungs. This study aimed to assess the influence on lung injuries of the way in which cardiac arrest was induced and to investigate the mechanisms leading to any differences. Male rats were allocated into three groups as follows: sham (no warm ischemia), ventricular fibrillation (VF), and asphyxia group. Cardiac arrest was induced by either VF by way of a fibrillator or asphyxia caused by withdrawal of ventilation, which reflected uncontrolled and controlled DCD situations, respectively. The impact on lung flushing after 60 min of warm ischemia time was evaluated (n = 5, in each group). The physiological functions of the lungs in an isolated lung perfusion circuit were also evaluated with warm ischemia time prolonged to 150 min (n = 8, in each group). Messenger RNA expression levels of surfactant proteins (SPs) and inflammatory cytokines, pathologic findings, and high-energy phosphates of the lung tissues were investigated. In the asphyxia group, flushing and physiological functions in the isolated lung perfusion circuit were the most severely affected. Reverse transcription-polymerase chain reaction and pathologic findings revealed depletion of surf...Continue Reading

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Citations

Sep 9, 2015·Current Opinion in Organ Transplantation·Fengshi Chen, Hiroshi Date
Nov 25, 2018·General Thoracic and Cardiovascular Surgery·Kyoko HijiyaHiroshi Date
Feb 2, 2021·Frontiers in Cardiovascular Medicine·Maria ArnoldSarah Longnus
Jun 3, 2021·Cells·Toyofumi Fengshi Chen-Yoshikawa

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