Impact of the distance from the stent edge to the residual plaque on edge restenosis following everolimus-eluting stent implantation

PloS One
Masao TakahashiIssei Komuro

Abstract

This study aimed to assess the relation between stent edge restenosis (SER) and the distance from the stent edge to the residual plaque using quantitative intravascular ultrasound. Although percutaneous coronary intervention with drug-eluting stents has improved SER rates, determining an appropriate stent edge landing zone can be challenging in cases of diffuse plaque lesions. It is known that edge vascular response can occur within 2 mm from the edge of a bare metal stent, but the distance to the adjacent plaque has not been evaluated for drug-eluting stents. A total of 97 proximal residual plaque lesions (plaque burden [PB] >40%) treated with everolimus-eluting stents were retrospectively evaluated to determine the distance from the stent edge to the residual plaque. The SER group had significantly higher PB (59.1 ± 6.1% vs. 51.9 ± 9.1% for non-SER; P = 0.04). Higher PB was associated with SER, with the cutoff value of 54.74% determined using receiver operating characteristic (ROC) curve analysis. At this cutoff value of PB, the distance from the stent edge to the lesion was significantly associated with SER (odds ratio = 2.05, P = 0.035). The corresponding area under the ROC curve was 0.725, and the cutoff distance value for...Continue Reading

References

Sep 19, 2001·Circulation·H MudraUNKNOWN OPTICUS (OPTimization with ICUS to reduce stent restenosis) Study Investigators
Jun 7, 2002·The New England Journal of Medicine·Marie-Claude MoriceUNKNOWN RAVEL Study Group. Randomized Study with the Sirolimus-Coated Bx Velocity Balloon-Expandable Stent in the Treatment of Patie
Oct 29, 2005·The American Journal of Cardiology·Ryota SakuraiUNKNOWN SIRIUS Trial Investigators
Jul 9, 2010·The American Journal of Cardiology·Takao ShimohamaKrishnankutty Sudhir
Feb 26, 2013·The American Journal of Cardiology·Soo-Jin KangSeung-Jung Park
Mar 8, 2013·The American Journal of Cardiology·Soo-Jin KangSeung-Jung Park

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Citations

Jul 21, 2016·The International Journal of Cardiovascular Imaging·Ayla HoogendoornJolanda J Wentzel
Feb 6, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Bu Chun ZhangEvelyn Regar
Dec 15, 2020·Current Pharmaceutical Design·Lei ZhangNan Huang

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Methods Mentioned

BETA
dissection
coronary artery bypass
dissections

Software Mentioned

echoPlaque
JMP

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