Impact of the experimental conditions on drug release from parenteral depot systems: From negligible to significant

International Journal of Pharmaceutics
C DelplaceFlorence Siepmann

Abstract

The aim of this study was to evaluate the impact of the experimental conditions on drug release measurements from parenteral depot systems. Frequently applied setups were used, including agitated and "non-agitated" flasks and tubes, flow-though cells as well as agarose gels. The bulk fluid volumes and flow rates were varied. Lipid implants (prepared by direct compression or melting & casting) as well as PLGA-based microparticles (prepared by O/W or W/O/W or S/O/W solvent extraction/evaporation methods) were studied. Theophylline, lidocaine, prilocaine, propranolol HCl, dexamethasone and ibuprofen were used as model drugs at different initial loadings. In all cases, the release medium was phosphate buffer pH 7.4, kept constant at 37°C. Particle size analysis, SEM, X-ray diffraction, DSC analysis and mathematical modeling were applied to better understand the observed phenomena. Interestingly, the importance of the impact of the experimental conditions ranged from negligible to significant, depending on the specific type of drug delivery system and setup. Both, lipid implants as well as PLGA-based microparticles can exhibit more or less sensitive/robust drug release patterns. The observed differences in sensitivity could partiall...Continue Reading

References

Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·J P BenoitP Menei
May 23, 2001·Advanced Drug Delivery Reviews·J Siepmann, A Göpferich
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·B H WooP P DeLuca
May 19, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Silke Mohl, Gerhard Winter
Jun 11, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Diane J BurgessMei-Ling Chen
Dec 14, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lei Li, Steven P Schwendeman
Nov 22, 2005·Expert Opinion on Drug Delivery·Philippe MeneiJean-Pierre Benoit
Dec 16, 2005·AAPS PharmSciTech·Susan S D'Souza, Patrick P DeLuca
Mar 23, 2006·International Journal of Pharmaceutics·C GuseA Goepferich
Apr 29, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Banu S ZolnikDiane J Burgess
May 2, 2006·International Journal of Pharmaceutics·J SiepmannA T Florence
Feb 6, 2007·Molecular Pharmaceutics·Jichao Kang, Steven P Schwendeman
Apr 7, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·S KoenningsA Goepferich
Apr 13, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·S KoenningsA Goepferich
Jul 24, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Banu S Zolnik, Diane J Burgess
Dec 7, 2007·International Journal of Pharmaceutics·D KloseJ Siepmann
Feb 20, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Banu S Zolnik, Diane J Burgess
Apr 30, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·F SiepmannJ Siepmann
Sep 30, 2008·International Journal of Pharmaceutics·J Siepmann, F Siepmann
Jan 6, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sandra Schulze, Gerhard Winter
Oct 8, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marilyn N MartinezMai Huynh
Nov 9, 2010·International Journal of Pharmaceutics·F KreyeJ Siepmann
Nov 26, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Susanne FredenbergAnders Axelsson
Mar 1, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·F KreyeJ Siepmann
Mar 12, 2011·International Journal of Pharmaceutics·Susanne FredenbergAnders Axelsson
Apr 6, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·F KreyeJ Siepmann
May 6, 2011·Journal of Pharmaceutical Sciences·Frauke KreyeJuergen Siepmann
Jun 7, 2011·International Journal of Pharmaceutics·Susanne FredenbergAnders Axelsson
Aug 2, 2011·International Journal of Pharmaceutics·J Siepmann, F Siepmann
Sep 6, 2011·International Journal of Pharmaceutics·Archana RawatDiane J Burgess
Oct 22, 2011·International Journal of Pharmaceutics·Jie Shen, Diane J Burgess
Oct 25, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Juergen Siepmann, Florence Siepmann
May 4, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·F KreyeJ Siepmann

❮ Previous
Next ❯

Citations

Jul 23, 2013·International Journal of Pharmaceutics·Juergen Siepmann
Dec 25, 2012·International Journal of Pharmaceutics·Mohammed ManiruzzamanDennis Douroumis
Jan 15, 2013·International Journal of Pharmaceutics·C Regnier-DelplaceJ Siepmann
Apr 30, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Claudia FloresNicolas Blanchemain
May 12, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bruno Gonçalves PereiraSílvia Ligório Fialho
Apr 14, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kimberley ElbrinkFilip Kiekens
Aug 15, 2021·International Journal of Pharmaceutics·Juan José CarrascalYolima Baena

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
F KreyeJuergen Siepmann
International Journal of Pharmaceutics
Archana RawatDiane J Burgess
© 2021 Meta ULC. All rights reserved