PMID: 9165143Apr 1, 1997Paper

Impact of the interfraction interval on clonogenic cell survival in split-dose irradiation of R1H rhabdomyosarcoma of the rat in vitro

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
H WillersH P Beck-Bornholdt

Abstract

In a previous study, the response of the R1H rhabdomyosarcoma of the rat to conventional irradiation (1.83-2.75 Gy fractions once-daily) and hyperfractionated radiotherapy (0.92-1.38 Gy fractions with different time intervals between the two daily fractions) was investigated [Kleineidam, M., Pieconka, A., Beck-Bornholdt, H.-P. Radiotherapy of the rhabdomyosarcoma R1H of the rat: influence of the time interval between two daily fractions during hyperfractionated radiotherapy. Radiother. Oncol. 30: 128-132, 1994]. Compared to once-daily irradiation, interfraction intervals of 2 h led to reduced tumour response, due to recovery from sublethal damage, and intervals of 5-6 h resulted in increased tumour response, possibly due to cell cycle effects. The purpose of the present study was to complement these tumour data by measuring clonogenic cell survival of R1H cells in vitro after split-dose irradiation. Experiments were performed with 2 x 2.5 Gy and 2 x 3.5 Gy either at 21 degrees C (preventing cell cycle progression) or at 37 degrees C (allowing for cell cycle effects). For 3.5 Gy fractions, a cell survival curve equivalent to the in vivo results was obtained with the lowest surviving fraction observed at time intervals of 6-7 h, ...Continue Reading

References

Dec 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K K AngY Feng
Feb 1, 1988·International Journal of Radiation Oncology, Biology, Physics·H Vogler, H P Beck-Bornholdt
May 1, 1987·International Journal of Radiation Oncology, Biology, Physics·H P Beck-BornholdtH Vogler
Apr 1, 1987·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S LaukK R Trott
Mar 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J Nyman, I Turesson
Nov 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H P Beck-Bornholdt, H H Dubben
Jun 15, 1995·International Journal of Radiation Oncology, Biology, Physics·K K FuP Rubin
Feb 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M KleineidamH P Beck-Bornholdt
Jan 15, 1996·International Journal of Radiation Oncology, Biology, Physics·B Jeremic, Y Shibamoto

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Citations

Aug 6, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A RaabeW Alberti
Apr 7, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C Clifton LingEllen Yorke

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