Impact of the introduction of a nucleic acid amplification test for Clostridium difficile diagnosis on stool rejection policies

Gut Pathogens
J GoretF Mégraud

Abstract

The change from non-molecular to nucleic acid amplification tests (NAATs) is known to increase the detection of Clostridium difficile infection (CDI); however, the impact on stool rejection policies in clinical laboratories is unclear. The current guidelines have reinforced the importance of respecting strict conditions for performing tests on stool samples for CDI diagnosis. The purpose of this study was to estimate whether the implementation of molecular tests has resulted in changes in stool rejection policies between clinical laboratories that introduced NAATs and those that did not. A survey was conducted to evaluate the change in the number of stool samples rejected and the rejection criteria among 12 hospital laboratories in southwestern France before and after the switch from non-molecular tests to NAATs using retrospective data from June 1 till September 30, 2013 and the same period 2014. Four laboratories introduced NAATs as a second or third step in the process. A total of 1378 and 1297 stools samples were collected in 2013 and 2014, respectively. The mean number of rejected stool samples significantly increased (p < 0.001, Chi square test), with a total of 99 (7.1%) and 147 (11.3%) specimens rejected in 2013 and 201...Continue Reading

References

Apr 30, 2004·The Journal of Infectious Diseases·Lennox K ArchibaldWilliam R Jarvis
Sep 1, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Jacques PépinDaniel Chouinard
Mar 28, 2006·The American Journal of Medicine·Sowjanya S MohanBurke A Cunha
May 18, 2006·Emerging Infectious Diseases·L Clifford McDonaldDaniel B Jernigan
Oct 11, 2008·Journal of Clinical Microbiology·Diana M Cardona, Kenneth H Rand
Apr 16, 2009·The American Journal of Gastroenterology·Hashim NematGisele Wolf-Klein
Nov 26, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M J T CrobachE J Kuijper
Jan 15, 2010·Journal of Clinical Microbiology·Susan M Novak-WeekleyAlice Weissfeld
Feb 24, 2010·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Philip M PolgreenJoseph E Cavanaugh
Mar 24, 2010·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Stuart H CohenUNKNOWN Infectious Diseases Society of America
Jun 24, 2011·Journal of Clinical Microbiology·Erik R DubberkeWilliam Michael Dunne
Aug 11, 2011·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Kimberlee S FongThomas G Fraser
Sep 6, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Abhishek DeshpandeAdrian V Hernandez
May 9, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L AlcaláUNKNOWN Spanish Clostridium difficile Study Group
Sep 27, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yves LongtinJean Longtin
Mar 19, 2013·Médecine et maladies infectieuses·C EckertUNKNOWN ICD-Raisin Working Group
Mar 26, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J D GreinA R Murthy
Sep 11, 2013·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Rebekah W MoehringDeverick J Anderson
Oct 15, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S B DebastUNKNOWN European Society of Clinical Microbiology and Infectious Diseases
Jan 31, 2014·Journal of Clinical Microbiology·Jessica CohenUNKNOWN CDC's Clostridium difficile Infection Surveillance Investigators
Apr 24, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L AlcaláUNKNOWN Spanish Clostridium difficile Study Group
Aug 25, 2015·Journal of Medical Microbiology·Mona AkbariVictor Novack
Jul 28, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M J T CrobachE J Kuijper
Sep 4, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K DaviesM H Wilcox

❮ Previous
Next ❯

Citations

Nov 6, 2018·Spinal Cord Series and Cases·Avi Ohry

❮ Previous
Next ❯

Methods Mentioned

BETA
nucleic acid amplification
PCR

Software Mentioned

IDSA
NAAT
ESCMID

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
A AdlerIsraeli Clostridium difficile Diagnostics Study Group
Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
C GateauF Barbut
© 2022 Meta ULC. All rights reserved