Impact of the Metabolic Syndrome on Mortality is Modified by Objective Short Sleep Duration

Journal of the American Heart Association
Julio Fernandez-MendozaEdward O Bixler

Abstract

To examine whether objective sleep duration is an effect modifier of the impact of metabolic syndrome (MetS) on all-cause and cardiovascular disease/cerebrovascular mortality. We addressed this question in the Penn State Adult Cohort, a random, general population sample of 1344 men and women (48.8±14.2 years) who were studied in the sleep laboratory and followed up for 16.6±4.2 years. MetS was defined by the presence of 3 or more of obesity (≥30 kg/m2), elevated total cholesterol (≥200 mg/dL), triglycerides (≥150 mg/dL), fasting glucose (≥100 mg/dL), and blood pressure (≥130/85 mm Hg). Polysomnographic sleep duration was classified into clinically meaningful categories. Among the 1344 participants, 22.0% of them died during the follow-up. We tested the interaction between MetS and polysomnographic sleep duration on mortality using Cox proportional hazard models controlling for multiple potential confounders (P<0.05). The hazard ratios (95% CI) of all-cause and cardiovascular disease/cerebrovascular mortality associated with MetS were 1.29 (0.89-1.87) and 1.49 (0.75-2.97) for individuals who slept ≥6 hours and 1.99 (1.53-2.59) and 2.10 (1.39-3.16) for individuals who slept <6 hours. Interestingly, this effect modification was pr...Continue Reading

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Citations

Feb 1, 2019·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Jan 30, 2020·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
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Mar 28, 2018·Chronobiology International·Narriane Chaves Pereira de HolandaElaine Cristina Marqueze
May 28, 2019·Journal of Cachexia, Sarcopenia and Muscle·Ronaldo D PiovezanDalva Poyares
Jan 28, 2021·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Dec 22, 2020·Current Sleep Medicine Reports·Caleb G Hsieh, Jennifer L Martin
Jul 1, 2021·International Archives of Occupational and Environmental Health·Paula R PienaarDale E Rae

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Methods Mentioned

BETA
blood drawn

Software Mentioned

SAS

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