Impact of the new American College of Cardiology/American Heart Association definition of hypertension on atherosclerotic vascular events in systemic lupus erythematosus

Annals of the Rheumatic Diseases
Konstantinos TseliosMurray Urowitz

Abstract

The 2017 American College of Cardiology/American Heart Association guidelines defined hypertension at ≥130/80 mm Hg. Studies on patients with connective tissue diseases were not considered. Our aim was to assess the impact of this definition on atherosclerotic vascular events (AVEs) in systemic lupus erythematosus. Individuals from the Toronto Lupus Clinic with at least 2 years of follow-up and no prior AVE were divided in three groups according to their mean blood pressure (BP) over that period (≥140/90 mm Hg, 130-139/80-89 mm Hg and <130/80 mm Hg). They were followed until the first occurrence of an AVE (fatal or non-fatal coronary artery disease, cerebrovascular event and peripheral vascular disease) or last visit. Groups were compared as per the baseline atherosclerotic risk factors. A multivariable time-dependent analysis was performed to adjust for the presence of other risk factors. Of 1532 patients satisfying the inclusion criteria, 155 (10.1%) had a BP ≥140/90 mm Hg, 316 (20.6%) 130-139/80-89 mm Hg and 1061 (69.3%) were normotensives. After a mean follow-up of 10.8 years, 124 AVEs were documented. The incidence rates were 18.9, 11.5 and 4.5 per 1000 patient-years for the three groups, respectively (p=0.0007 between the...Continue Reading

References

Jul 30, 2008·Current Rheumatology Reports·Murray B Urowitz, Dafna D Gladman
Mar 21, 2009·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Chun-Yan ZhangChun-De Bao
Apr 28, 2009·Lupus·A CypieneA Laucevicius
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Jun 11, 2010·Arthritis Care & Research·M B UrowitzUNKNOWN Systemic Lupus International Collaborating Clinics
Aug 21, 2013·Seminars in Arthritis and Rheumatism·Konstantinos TseliosDafna D Gladman
Nov 14, 2013·Journal of the American Pharmacists Association : JAPhA
Nov 10, 2015·The New England Journal of Medicine·UNKNOWN SPRINT Research GroupWalter T Ambrosius
Nov 17, 2015·The Journal of Rheumatology·Konstantinos TseliosMurray B Urowitz
Feb 18, 2016·The Journal of Rheumatology·Murray B UrowitzDafna D Gladman
Feb 3, 2019·The Journal of Rheumatology·Murray B UrowitzDafna D Gladman

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