Impact of the resident microbiota on the nutritional phenotype of Drosophila melanogaster.

PloS One
Emma V RidleyAngela E Douglas

Abstract

Animals are chronically infected by benign and beneficial microorganisms that generally promote animal health through their effects on the nutrition, immune function and other physiological systems of the host. Insight into the host-microbial interactions can be obtained by comparing the traits of animals experimentally deprived of their microbiota and untreated animals. Drosophila melanogaster is an experimentally tractable system to study host-microbial interactions. The nutritional significance of the microbiota was investigated in D. melanogaster bearing unmanipulated microbiota, demonstrated by 454 sequencing of 16S rRNA amplicons to be dominated by the α-proteobacterium Acetobacter, and experimentally deprived of the microbiota by egg dechorionation (conventional and axenic flies, respectively). In axenic flies, larval development rate was depressed with no effect on adult size relative to conventional flies, indicating that the microbiota promotes larval growth rates. Female fecundity did not differ significantly between conventional and axenic flies, but axenic flies had significantly reduced metabolic rate and altered carbohydrate allocation, including elevated glucose levels. We have shown that elimination of the resi...Continue Reading

References

Jul 1, 1995·American Journal of Hematology·V R ArrudaP H Reitsma
Oct 6, 1998·Applied and Environmental Microbiology·T Fukatsu, N Nikoh
Jun 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Craig S StumpK Sreekumaran Nair
Dec 4, 2003·Annual Review of Entomology·R J Dillon, V M Dillon
Aug 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ted BrummelSeymour Benzer
Dec 2, 2006·Nature Reviews. Genetics·Bruce A Edgar
Jan 12, 2007·Nature·Margaret McFall-Ngai
Apr 3, 2007·Applied and Environmental Microbiology·Vanessa Corby-HarrisDaniel E L Promislow
Feb 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kwang Pum LeeDavid Raubenheimer
Mar 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Michael A MahowaldJeffrey I Gordon
Jul 30, 2009·Environmental Microbiology·Maria L MarcoMichiel Kleerebezem
Nov 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Hua ZhangLeslie Pick
Nov 7, 2009·Science·Elizabeth K CostelloRob Knight
Nov 20, 2009·Microbial Ecology·Courtney J RobinsonJo Handelsman
Dec 17, 2009·The Biochemical Journal·Aurelio A Teleman
Jan 14, 2010·Annals of Nutrition & Metabolism·Carol S JohnstonRomina H Ryals
Mar 6, 2010·Science·Matam Vijay-KumarAndrew T Gewirtz
Jun 10, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Koen Venema
Jul 29, 2010·The ISME Journal·Jeremiah J FaithJeffrey I Gordon
Sep 2, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M DiamantW M de Vos
Jan 5, 2011·Environmental Microbiology·Diana R NemergutRob Knight
Jun 3, 2011·Environmental Microbiology·Chun Nin Adam WongAngela E Douglas
Jun 17, 2011·Nature·Andrew L KauJeffrey I Gordon

❮ Previous
Next ❯

Citations

Sep 5, 2014·Microbial Cell Factories·Renata C Matos, François Leulier
Nov 26, 2014·Nature Reviews. Immunology·Nicolas BuchonSara Cherry
Apr 17, 2014·Journal of Molecular Biology·Angela E Douglas
Mar 12, 2013·Applied and Environmental Microbiology·Emma V RidleyAngela E Douglas
Nov 19, 2013·Applied and Environmental Microbiology·Peter D Newell, Angela E Douglas
Jun 25, 2013·Journal of Chemical Ecology·Angela E Douglas
May 31, 2013·The ISME Journal·Adam C-N WongAngela E Douglas
Jun 13, 2015·Biomedical Journal·Laure El ChamyJean-Marc Reichhart
Feb 2, 2016·Developmental and Comparative Immunology·Maura Strigini, François Leulier
Dec 24, 2015·Environmental Microbiology·Ana LokmerKarl Mathias Wegner
Apr 4, 2016·Trends in Ecology & Evolution·Michael Shapira
May 6, 2015·Oecologia·Tobin J Hammer, M Deane Bowers
Apr 16, 2016·Nature Communications·Michael ElgartYoav Soen
May 23, 2013·FEMS Microbiology Reviews·Philipp Engel, Nancy A Moran
Feb 24, 2015·FEMS Microbiology Reviews·Hadar NeumanOmry Koren
May 20, 2016·International Journal of Genomics·Simon BahrndorffJeppe Lund Nielsen
May 11, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Nichole A Broderick
Aug 21, 2013·PLoS Neglected Tropical Diseases·Yixin H YeElizabeth A McGraw
Mar 13, 2015·PLoS Genetics·Robert L UncklessBrian P Lazzaro
Sep 11, 2013·Annual Review of Genetics·Bruno Lemaitre, Irene Miguel-Aliaga
Oct 11, 2016·Frontiers in Microbiology·Jessica DittmerRobert M Brucker
Jan 28, 2014·PloS One·Tobin J HammerNoah Fierer
May 19, 2017·PloS One·Gerrit LochMichael Hoch
Jun 21, 2017·Proceedings of the National Academy of Sciences of the United States of America·Kerri L CoonMichael R Strand
Dec 8, 2017·Calcified Tissue International·Martin SchwarzerFrançois Leulier
Dec 22, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Michael Elgart, Yoav Soen
Mar 28, 2018·Gut Pathogens·Khachik E LabachyanMahtab Jafari
Jul 31, 2013·Nature Reviews. Microbiology·Nicolas BuchonBruno Lemaitre

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

StandAlone BLAST
454 Life Science
Sable System
Pyrotagger

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.