Impact of the Serum Uric Acid Level on Subclinical Atherosclerosis in Middle-aged and Elderly Chinese

Journal of Atherosclerosis and Thrombosis
Ying ChenGuang Ning

Abstract

The carotid intima-media thickness (CIMT) is now validated as a sensitive marker of atherosclerosis and is directly associated with an increased risk of cardiovascular disease. Considering that the independent association between the serum uric acid level and CIMT remains controversial due to the complex interrelationship with other known cardiovascular risk factors, further studies are needed. The aim of the present study is to explore the association between the serum uric acid level and CIMT in a general Chinese population and determine whether the association differs according to varied metabolic status. The present study was cross-sectional in design. A total of 10,281 community-based participants 40 years of age or older from Shanghai, China were included in the current analysis. All participants underwent a detailed questionnaire interview, anthropometric measurements and ultrasonography to assess the CIMT. Blood and urine samples were collected for the biochemical measurements. The serum uric acid levels were positively associated with obesity- and diabetes-related parameters and the CIMT. In a logistic regression model controlling for potential confounders, compared with the participants in the first quartile of the ur...Continue Reading

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Citations

Feb 19, 2016·Journal of Atherosclerosis and Thrombosis·Wen ZhangUNKNOWN EPOCH-JAPAN GROUP
Sep 1, 2015·Journal of Atherosclerosis and Thrombosis·Ying ChenWeiqing Wang
Dec 3, 2016·Journal of Atherosclerosis and Thrombosis·Wen ZhangUNKNOWN EPOCH-JAPAN GROUP
Feb 17, 2017·Journal of Atherosclerosis and Thrombosis·Yoko SotodaIchiro Wakabayashi
Sep 1, 2015·Journal of Atherosclerosis and Thrombosis·Battal AltunKadir Ozturk
Sep 20, 2020·International Journal of Clinical Practice·Hyeon Hui KangHyuk-Jae Chang
Apr 11, 2021·Aging Clinical and Experimental Research·Li-Hui PengJie Chen

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