Impact of the single-dose immunization strategy against hepatitis A in Argentina

The Pediatric Infectious Disease Journal
Carla VizzottiMáximo Diosque

Abstract

After a country wide outbreak occurred during 2003-2004, 1 dose of hepatitis A vaccine was introduced into Argentinian regular immunization schedule for all children aged 12 months in June 2005. The aim of this study was to assess the impact of this novel intervention. A longitudinal analysis was done of hepatitis A virus (HAV) infection rates reported to the National Epidemiological Surveillance System from 2000 to 2011. Occurrence of fulminant hepatic failure (FHF) and liver transplantation cases up to 2011 were also assessed. Incidence rates and clinical impact were compared between pre- and postvaccination periods (2000-2002 vs. 2006-2011). Notification rates were also compared by age groups and geographical regions. Since 2006, an abrupt decline was observed in HAV infection rates, as well as in FHF and liver transplantation cases. The mean incidence rate of 7.9/100,000 in the postvaccination period represents a reduction of 88.1% (P < 0.001) when compared with the prevaccination period. Neither FHF nor liver transplantation due to HAV infection were observed since March 2007. Decline in incidence rates was evident in all geographical regions and all age groups but was higher in the prevaccination most affected areas and i...Continue Reading

References

Aug 13, 1992·The New England Journal of Medicine·A WerzbergerG Calandra
Jun 10, 1998·Lancet·R S Koff
Dec 26, 2001·JAMA : the Journal of the American Medical Association·F AverhoffH S Margolis
Feb 27, 2003·Journal of Paediatrics and Child Health·C R MacIntyreP B McIntyre
Aug 23, 2003·The Journal of Infectious Diseases·Orlando Mayorga PérezMatthias Egger
Apr 16, 2005·International Journal of Epidemiology·K H Jacobsen, J S Koopman
Jun 21, 2005·Vaccine·M Teresa ValenzuelaBruce L Innis
Jul 15, 2005·JAMA : the Journal of the American Medical Association·Annemarie WasleyBeth P Bell
Jul 15, 2005·JAMA : the Journal of the American Medical Association·Ron DaganDaniel Shouval
Sep 1, 2007·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·Alejandro EllisBruce L Innis
Sep 13, 2007·The Pediatric Infectious Disease Journal·Mirta CioccaJohn Weil
Sep 18, 2007·Archives of Disease in Childhood·M CioccaF Alvarez
Oct 22, 2008·Journal of Viral Hepatitis·M N Vacchino
Mar 18, 2011·Clinical and Vaccine Immunology : CVI·Christoph HatzChristian Herzog

❮ Previous
Next ❯

Citations

Oct 28, 2015·Human Vaccines & Immunotherapeutics·Fernando CarlosLuis Romano-Mazzotti
Feb 27, 2015·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·H LevineR Dagan
Dec 8, 2016·Human Vaccines & Immunotherapeutics·Ignasi ParrónUNKNOWN Working Group for the Study of Hepatitis A in Catalonia
Oct 28, 2016·Human Vaccines & Immunotherapeutics·Anke L StuurmanDaniel Shouval
Apr 18, 2018·Cold Spring Harbor Perspectives in Medicine·Daniel Shouval
Sep 14, 2016·Biomédica : revista del Instituto Nacional de Salud·Paula Andrea BáezMaría Cristina Navas
Jul 24, 2015·Current Opinion in Infectious Diseases·Rakesh Aggarwal, Amit Goel
Jul 25, 2019·Revista da Associação Médica Brasileira·José Colleti JuniorWerther Brunow de Carvalho
Dec 23, 2017·Applied and Environmental Microbiology·G MasachessiV Ré
Sep 22, 2020·Expert Review of Vaccines·Anar AndaniKathryn H Jacobsen
Sep 29, 2020·Journal of Medical Virology·Kaouther AyouniJihène Bettaieb
Jun 28, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fuzhen WangLiping Shen
Dec 17, 2020·Human Vaccines & Immunotherapeutics·Christian HerzogPierre Van Damme
May 1, 2021·Vaccines·Ana Luiza BierrenbachThais das Neves Fraga Moreira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.