Abstract
The UK Prospective Diabetes Study (UKPDS) is a group of clinical trials, epidemiological analyses and health-modelling studies with an influence which can be assessed across a broad range of health domains. Original publications (n = 85) are notable for being mainly published in the key weekly or diabetes journals (78%) and being mainly in the clinical arena (68%). Notable reference to the publications can be found in UK National Institute for Clinical Excellence (NICE) guidelines, but also in evidence-based international guidelines, where UKPDS papers form a significant fraction of the citations. In educational materials UKPDS-derived slides remain popular (10 and 30% of some international slide sets), again as much for the epidemiological findings as for the core trial results. Slides of the deterioration in blood glucose control with time, and evidence that this is as a result of progressive decline of pancreatic islet B-cell function, are used particularly often. The UKPDS enhanced the promotion of glycated haemoglobin to its core role in clinical monitoring, through understanding of the quantitative relationship of vascular complications to glucose control, and thus to target setting. Notably, metformin therapy was promote...Continue Reading
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