Impact of therapeutic delay in colorectal cancer on overall survival and cancer recurrence - is there a safe timeframe for prehabilitation?

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Maud T A StrousF Jeroen Vogelaar

Abstract

Interest in adoption of a prehabilitation programme in management of colorectal cancer is increasing, but current waiting time targets leave no opening for intervention. Prompt treatment following diagnosis is demanded but defending evidence is lacking. We aimed to investigate the impact of prolonged therapeutic delay on overall and cancer-free survival in patients with primary colorectal cancer. Retrospective analysis was performed in a detailed dataset of patients with primary colorectal cancer who underwent curative surgical treatment between January 2010 and December 2016. Groups were made according to therapeutic delay ≤35 days or >35 days. Endpoints were overall and cancer-free survival, assessed with Kaplan-Meier survival curves, log-rank tests and Cox proportional hazard analyses. A total of 790 patients were included of whom 559 had a colonic tumour and 231 a rectal tumour. Median therapeutic delay was 32 days (IQR 26-43 days). Multivariate analysis showed therapeutic delay >35 days was not associated with poorer overall survival (HR = 1.202, p = 0.249) or earlier cancer recurrence (HR = 1.256, p = 0.212). Similar results were found when stratifying analyses for colonic and rectal cancer, and when defining prolonged de...Continue Reading

Citations

Apr 3, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Eva Angenete
May 7, 2020·Current Opinion in Anaesthesiology·Enrico Maria MinnellaFrancesco Carli
Feb 24, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Mathias NeronMichel Fabbro
Mar 21, 2021·International Journal of Colorectal Disease·A K WarpsUNKNOWN Dutch ColoRectal Audit
Mar 14, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Thomas M WhittakerGethin L Williams
Apr 5, 2021·World Journal of Surgery·Charlotte J L MolenaarGerrit D Slooter
Dec 24, 2019·Innovative Surgical Sciences·Charlotte J L MolenaarGerrit D Slooter
May 15, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Ruud F W FranssenMaryska L G Janssen-Heijnen
Jun 10, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M de KlerkE G G Verdaasdonk
Jun 28, 2021·World Journal of Surgery·Ruud F W FranssenMaryska L G Janssen-Heijnen

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