Impact of Thyroid Hormone Therapy on Atherosclerosis in the Elderly With Subclinical Hypothyroidism: A Randomized Trial

The Journal of Clinical Endocrinology and Metabolism
Manuel BlumNicolas Rodondi

Abstract

Subclinical hypothyroidism (SHypo) has been associated with atherosclerosis, but no conclusive clinical trials assessing the levothyroxine impact on carotid atherosclerosis exist. To assess the impact of treatment of SHypo with levothyroxine on carotid atherosclerosis. Randomized, double-blind, placebo-controlled trial nested within the Thyroid Hormone Replacement for Subclinical Hypothyroidism trial. Participants aged ≥65 years with SHypo [thyroid-stimulating hormone (TSH), 4.60 to 19.99 mIU/L; free thyroxine level within reference range]. Levothyroxine dose-titrated to achieve TSH normalization or placebo, including mock titrations. Carotid intima media thickness (CIMT), maximum plaque thickness measured with ultrasound. One hundred eighty-five participants (mean age 74.1 years, 47% women, 96 randomized to levothyroxine) underwent carotid ultrasound. Overall mean TSH ± SD was 6.35 ± 1.95 mIU/L at baseline and decreased to 3.55 ± 2.14 mIU/L with levothyroxine compared with 5.29 ± 2.21 mIU/L with placebo (P < 0.001). After a median treatment of 18.4 months (interquartile range 12.2 to 30.0 months), mean CIMT was 0.85 ± 0.14 mm under levothyroxine and 0.82 ± 0.13 mm under placebo [between-group difference = 0.02 mm; 95% CI, -0.0...Continue Reading

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References

Dec 3, 2002·The American Journal of Medicine·Deborah GradyElizabeth Barrett-Connor
Mar 7, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J R ZanchettaS L Myers
Nov 18, 2003·Clinical Endocrinology·Toshiki NagasakiYoshiki Nishizawa
Jun 28, 2006·Circulation·Jean-Claude TardifPeter Libby
Mar 27, 2007·JAMA : the Journal of the American Medical Association·John R CrouseUNKNOWN METEOR Study Group
Nov 10, 2007·Endocrine Reviews·Bernadette Biondi, David S Cooper
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Jul 1, 2009·BMJ : British Medical Journal·Jonathan A C SterneJames R Carpenter
Nov 17, 2009·The New England Journal of Medicine·Allen J TaylorMark Turco
Jul 20, 2010·BMJ : British Medical Journal·Eveline NüeschPeter Jüni
Sep 23, 2010·JAMA : the Journal of the American Medical Association·Nicolas RodondiUNKNOWN Thyroid Studies Collaboration
Aug 14, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Lars LindUNKNOWN METEOR Study Group
Nov 29, 2012·European Heart Journal·Lian EngelenUNKNOWN Reference Values for Arterial Measurements Collaboration
May 2, 2014·European Thyroid Journal·Simon H S PearceJean-Louis Wemeau
Nov 26, 2016·BMJ Open·Ran SturlaugsdottirVilmundur Gudnason
Apr 13, 2017·The New England Journal of Medicine·David J StottUNKNOWN TRUST Study Group

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Citations

Oct 28, 2018·Hormone Molecular Biology and Clinical Investigation·Simonetta LugariAmedeo Lonardo
Apr 14, 2020·JAAPA : Official Journal of the American Academy of Physician Assistants·Chelsea SimonSarah Allen
Sep 5, 2019·Endocrine·Leonidas H Duntas, Paul Michael Yen
Jan 31, 2020·Frontiers in Endocrinology·Angeliki StamatouliSahzene Yavuz
May 27, 2020·International Journal of Endocrinology·Xiaochun MaXiaoming Zhou
Mar 29, 2020·Expert Review of Endocrinology & Metabolism·Owain Leng, Salman Razvi
Jul 10, 2019·JAMA : the Journal of the American Medical Association·Bernadette BiondiDavid S Cooper
Aug 23, 2020·International Journal of Molecular Sciences·Daniela Maria TanaseMariana Floria
Jun 5, 2020·Cardiovascular Drugs and Therapy·Yunxiao YangMing Zhang
Nov 17, 2020·Frontiers in Endocrinology·Laura Y Sue, Angela M Leung

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