Impact of time-of-flight PET on quantification errors in MR imaging-based attenuation correction

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Abolfazl Mehranian, Habib Zaidi

Abstract

Time-of-flight (TOF) PET/MR imaging is an emerging imaging technology with great capabilities offered by TOF to improve image quality and lesion detectability. We assessed, for the first time, the impact of TOF image reconstruction on PET quantification errors induced by MR imaging-based attenuation correction (MRAC) using simulation and clinical PET/CT studies. Standard 4-class attenuation maps were derived by segmentation of CT images of 27 patients undergoing PET/CT examinations into background air, lung, soft-tissue, and fat tissue classes, followed by the assignment of predefined attenuation coefficients to each class. For each patient, 4 PET images were reconstructed: non-TOF and TOF both corrected for attenuation using reference CT-based attenuation correction and the resulting 4-class MRAC maps. The relative errors between non-TOF and TOF MRAC reconstructions were compared with their reference CT-based attenuation correction reconstructions. The bias was locally and globally evaluated using volumes of interest (VOIs) defined on lesions and normal tissues and CT-derived tissue classes containing all voxels in a given tissue, respectively. The impact of TOF on reducing the errors induced by metal-susceptibility and respir...Continue Reading

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Citations

Feb 18, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Ryogo MinamimotoAndrei Iagaru
Feb 18, 2016·EJNMMI Physics·S VandenbergheJ S Karp
Mar 10, 2016·PET Clinics·David Izquierdo-Garcia, Ciprian Catana
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