Impact of time to antibiotic on hospital stay, intensive care unit admission, and mortality in febrile neutropenia

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Lisa M DanielsPritish K Tosh

Abstract

To determine if time to antibiotics (TTA) improves outcomes of hospital length of stay, admission to the intensive care unit, and 30-day mortality in adult patients with febrile neutropenia. This retrospective cohort study evaluated the impact of time to antibiotic, in the treatment of febrile neutropenia, on hospital length of stay, admission to the intensive care unit, and 30-day mortality. Cases included were patients 18 years or older hospitalized with febrile neutropenia from August 1, 2006 to July 31, 2016. To adjust for other characteristics associated with hospital length of stay, admission to the intensive care unit, and 30-day mortality, a multivariate analysis was performed. A total of 3219 cases of febrile neutropenia were included. The median hospital length of stay was 7.0 days (IQR 4.1-13.3), rate of intensive care unit admission was 13.6%, and 30-day mortality was 6.6%. Multivariate analysis demonstrated time to antibiotics was not associated with hospital length of stay but was associated with admission to the intensive care unit admission and 30-day mortality. Delays in time to antibiotic of up to 3 hours did not impact outcomes. A shorter time to antibiotic is important in treatment of febrile neutropenia; ho...Continue Reading

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Citations

Jul 3, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Christa KoenigBob Phillips
Jan 9, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Steven T WalkerJason Trubiano
May 21, 2020·Journal of Clinical Medicine·Olivier PeyronySylvie Chevret
Sep 8, 2020·Expert Review of Anti-infective Therapy·Andrew M PeseskiHeiko Konig
Mar 19, 2021·The American Journal of Emergency Medicine·Charles B KemmlerSean D Foster
Feb 1, 2022·Journal of the Pediatric Infectious Diseases Society·Rachel L Wattier, Adam J Esbenshade

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