Impact of Timing following Acute Myocardial Infarction on Efficacy and Safety of Bone Marrow Stem Cells Therapy: A Network Meta-Analysis

Stem Cells International
Bei LiuMin-Sheng Chen

Abstract

Background. The optimal timing for Bone Marrow Stem Cells (BMCs) therapy following acute myocardial infarction (AMI) remains unclear. Aims. To synthesize the evidence from trials using a multiple-treatment comparison method, thereby permitting a broader comparison across multiple timing of BMCs therapy. Methods and Results. Randomized controlled trials in patients with AMI receiving BMCs therapy were identified from PubMed, Ovid LWW, BIOSIS Previews, and the Cochrane Library through January 2015. 2 035 patients of 31 studies included in our analysis were allocated to 5 groups' treatments: 1~3 days, 4~7 days, 8~14 days, 15~30 days, or placebo/control group. The multiple-treatment meta-analysis showed that 4~7 days' group could lead to significantly increased left ventricular ejection fraction (LVEF) as compared with control (mean of MDs and 95% CI: 6 months, 3.05 (0.92~5.25); 12 months, 4.18 (2.30~5.84)). Only 4~7 days led to significant reduction of MACEs compared with control (OR and 95% CI 0.34 (0.13~0.96)) for 12-months follow-up. In simulated comparisons, the 4~7 days' group ranked better than other timing groups for improvement of LVEF or reduction of the incidence of major adverse cardiac events. Conclusions. 4~7 days aft...Continue Reading

References

Jul 7, 2001·BMJ : British Medical Journal·P JüniM Egger
Jan 30, 2004·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Shaoheng ZhangLinsong Li
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·Jozef BartunekMarc Vanderheyden
Sep 23, 2006·The New England Journal of Medicine·Volker SchächingerUNKNOWN REPAIR-AMI Investigators
Jun 5, 2008·European Heart Journal·Enca Martin-RendonSuzanne M Watt
Dec 10, 2009·Circulation. Heart Failure·Birgit AssmusUNKNOWN REPAIR-AMI Investigators
Nov 17, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Massimo CastellaniPaolo Gerundini
Sep 3, 2011·Journal of the American College of Cardiology·Bodo-Eckehard Strauer, Gustav Steinhoff
Nov 16, 2011·JAMA : the Journal of the American Medical Association·Jay H TraverseUNKNOWN Cardiovascular Cell Therapy ResearchNetwork
May 7, 2013·Journal of Molecular and Cellular Cardiology·Xiaoxiang YanMotoaki Sano

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Citations

Oct 1, 2019·Journal of Cellular and Molecular Medicine·Felicia CarotenutoPaolo Di Nardo
May 2, 2020·Journal of Clinical Medicine·Ming-Long ChangHsiu-Hu Lin
Jul 4, 2017·Expert Opinion on Biological Therapy·Pushpinder Kanda, Darryl R Davis

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Software Mentioned

BIOSIS Previews
TIME
meta
R
gemtc
Ovid LWW
LateTIME

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