Impact of timing of adjuvant chemotherapy on survival in stage III colon cancer: a population-based study

BMC Cancer
Peng GaoZhenning Wang

Abstract

There is no consensus regarding the optimal time to initiate adjuvant chemotherapy after surgery for stage III colon cancer, and the relevant postoperative complications that cause delays in adjuvant chemotherapy are unknown. Eligible patients aged ≥66 years who were diagnosed with stage III colon cancer from 1992 to 2008 were identified using the linked Surveillance, Epidemiology, and End Results-Medicare database. Kaplan-Meier analysis and a Cox proportional hazards model were utilized to evaluate the impact of the timing of adjuvant chemotherapy on overall survival (OS). A total of 18,491 patients were included. Delayed adjuvant chemotherapy was associated with worse OS (9-12 weeks: hazard ratio [HR] = 1.222, 95% confidence interval [CI] = 1.063-1.405; 13-16 weeks: HR = 1.252, 95% CI = 1.041-1.505; ≥ 17 weeks: HR = 1.969, 95% CI = 1.663-2.331). The efficacies of adjuvant chemotherapy within 5-8 weeks and ≤4 weeks were similar (HR = 1.045, 95% CI = 0.921-1.185). Compared with the non-chemotherapy group, chemotherapy initiated at ≥21 weeks did not significantly improve OS (HR = 0.882, 95% CI = 0.763-1.018). Patients with postoperative complications, particularly cardiac arrest, ostomy infection, shock, and septicemia, had a si...Continue Reading

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Citations

May 13, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Antara BanerjeeSusmita Roy
Sep 4, 2020·World Journal of Gastrointestinal Oncology·Sakti ChakrabartiAmit Mahipal
Sep 30, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Miquell O MillerGareth J Morris-Stiff
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Sep 15, 2021·International Journal of Cancer. Journal International Du Cancer·Jemma M BoyleAjay Aggarwal
Nov 6, 2021·American Journal of Obstetrics and Gynecology·Logan CoreyIra Winer

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Methods Mentioned

BETA
surgical resection

Software Mentioned

SAS
R
SPSS
STATA

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