Impact of timing of surgery in elderly hip fracture patients: a systematic review and meta-analysis

Scientific Reports
Thomas KlestilBarbara Nussbaumer-Streit

Abstract

We aimed to assess the impact of timing of surgery in elderly patients with acute hip fracture on morbidity and mortality. We systematically searched MEDLINE, the Cochrane Library, Embase, PubMed, and trial registries from 01/1997 to 05/2017, as well as reference lists of relevant reviews, archives of orthopaedic conferences, and contacted experts. Eligible studies had to be randomised controlled trials (RCTs) or prospective cohort studies, including patients 60 years or older with acute hip fracture. Two authors independently assessed study eligibility, abstracted data, and critically appraised study quality. We conducted meta-analyses using the generic inverse variance model. We included 28 prospective observational studies reporting data of 31,242 patients. Patients operated on within 48 hours had a 20% lower risk of dying within 12 months (risk ratio (RR) 0.80, 95% confidence interval (CI) 0.66-0.97). No statistical significant different mortality risk was observed when comparing patients operated on within or after 24 hours (RR 0.82, 95% CI 0.67-1.01). Adjusted data demonstrated fewer complications (8% vs. 17%) in patients who had early surgery, and increasing risk for pressure ulcers with increased time of delay in anothe...Continue Reading

References

Mar 1, 1992·The Journal of Bone and Joint Surgery. British Volume·M J Parker, G A Pryor
Jun 6, 1996·The New England Journal of Medicine·J D Zuckerman
Aug 18, 1997·The American Journal of Medicine·A R Lyons
Jun 13, 1998·Annals of Internal Medicine·R S MorrisonA L Siu
Dec 1, 1998·JAMA : the Journal of the American Medical Association·J Zhang, K F Yu
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Apr 15, 2004·JAMA : the Journal of the American Medical Association·Gretchen M OroszAlbert L Siu
Jul 29, 2005·The Journal of Bone and Joint Surgery. British Volume·A W SiegmethM J Parker
Jul 1, 2006·BMJ : British Medical Journal·Martyn Parker, Antony Johansen
Sep 7, 2007·ANZ Journal of Surgery·Hamish C RaeTeodora Todorova
Mar 4, 2008·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Toshiya ShigaYoko Ohe
Jul 3, 2008·The Journal of Bone and Joint Surgery. American Volume·Amer N Al-AniMargareta Hedström
Dec 31, 2008·BMC Musculoskeletal Disorders·Rüdiger SmektalaLudger Pientka
May 6, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S MaggiUNKNOWN Hip Fracture Study Group
May 14, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B Abrahamsen, P Vestergaard
Aug 26, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B EttingerL J Melton
Oct 6, 2009·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Toshiro YonezawaShu Obara
Dec 10, 2009·Acta Orthopaedica·Arunas VertelisHans Wingstrand
Mar 2, 2010·Journal of Clinical Epidemiology·Yngve Falck-YtterGordon Guyatt
Mar 17, 2010·Annals of Internal Medicine·Patrick HaentjensSteven Boonen
Mar 24, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J LangleyA J Campbell
May 24, 2011·BMC Musculoskeletal Disorders·Jorma PanulaSirkka-Liisa Kivelä
Aug 17, 2011·Annals of Internal Medicine·María T VidánJosé A Serra
Dec 20, 2011·Archives of Gerontology and Geriatrics·Giulio PioliMaria Lia Lunardelli
Mar 16, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisUNKNOWN IOF Working Group on Epidemiology and Quality of Life
Mar 29, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Giulio PioliMaria Lia Lunardelli
Sep 1, 2010·Geriatric Orthopaedic Surgery & Rehabilitation·Scott SchnellStephen L Kates
Jul 19, 2013·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·K S HapuarachchiM G Bowditch
Sep 10, 2013·Journal of Orthopaedic Surgery·Keng Soon Poh, K Lingaraj
Nov 20, 2013·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·UNKNOWN Hip Fracture Accelerated Surgical Treatment and Care Track (HIP ATTACK) Investigators
Sep 19, 2014·World Journal of Orthopedics·Pedro CarpinteroManuel Mesa
Jan 9, 2015·The Bone & Joint Journal·C P Bretherton, M J Parker
Jan 28, 2015·The Journal of the American Academy of Orthopaedic Surgeons·Karl C RobertsKaitlyn Sevarino
May 20, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A MarquesUNKNOWN Portuguese Working Group for the Study of the Burden of Hip Fractures in Portugal
Jun 6, 2015·Archives of Gerontology and Geriatrics·Hanna M PajulammiMaria S Nuotio
Aug 20, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J LealUNKNOWN REFReSH study group
Jun 1, 2013·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·M MuhmH Winkler
Apr 9, 2016·Singapore Medical Journal·Lester Teong Jin TanErnest Beng Kee Kwek
May 12, 2016·Injury·Alejandro Lizaur-UtrillaFernando A Lopez-Prats
Sep 3, 2016·Clinical Orthopaedics and Related Research·John E LawrenceAndrew D Carrothers

❮ Previous
Next ❯

Citations

Sep 1, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·G ValentinB L Langdahl
Sep 8, 2019·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Nobuaki ChinzeiYasuhiro Saegusa
Oct 28, 2019·Acta Anaesthesiologica Scandinavica·Johan KristianssonBengt Nellgård
Feb 28, 2020·Journal of Palliative Medicine·Elizabeth A Bukowy, Elizabeth Thiel
Apr 3, 2020·Anaesthesia·A Mayor, S M White
Apr 24, 2020·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Anthony V ChristianoRohit Hasija
Jun 12, 2020·Journal of the American Geriatrics Society·Liron SinvaniGisele P Wolf-Klein
Jul 16, 2020·Journal of Clinical Medicine·Seth M TarrantZsolt J Balogh
Aug 8, 2019·Current Pain and Headache Reports·Anis DizdarevicKarina Gritsenko
Aug 31, 2020·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·Alessandro ApratoAlessandro Massè
Jun 13, 2020·BMC Musculoskeletal Disorders·Maic WernerEmmanouil Liodakis
Sep 11, 2020·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Maximiliano BarahonaJaime Catalan
Aug 28, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Eric Wei Liang CherJoyce Suang Bee Koh
Aug 31, 2020·Geriatric Orthopaedic Surgery & Rehabilitation·Henk Jan SchuijtDetlef van der Velde
Mar 29, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K PengL Si
Oct 11, 2020·BMC Health Services Research·Katie J SheehanUNKNOWN Canadian Collaborative Study on Hip Fractures
Nov 11, 2020·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·Xiang-Dong WuWei Huang
Dec 8, 2020·Current Opinion in Anaesthesiology·Manuel Wenk, Sönke Frey
Jan 7, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Cecilie DahlTone Kristin Omsland
Jan 21, 2021·International Journal of Environmental Research and Public Health·Rafael Prieto-MorenoMorten Tange Kristensen
Feb 2, 2021·The Bone & Joint Journal·Sara Marie NilsenJohan Håkon Bjørngaard
Dec 15, 2020·BMC Musculoskeletal Disorders·Jason TalevskiGustavo Duque
Nov 21, 2020·Bone & Joint Open·David R W MacDonaldUNKNOWN SCORE authors
Mar 3, 2021·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·Georgios OrfanosBishoy Youssef
Mar 16, 2021·Annals of the Royal College of Surgeons of England·K Malik-TabassumG Arealis

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