Impact of tobacco and alcohol consumption in patients registered on waiting list on early morbidity following liver transplantation

Clinics and Research in Hepatology and Gastroenterology
Pascal PerneyGeorges-Philippe Pageaux

Abstract

Liver transplantation (LT) is a high-risk surgery associated with postoperative complications. Smoking and drinking are known risk factors of long-term post-LT complications, but their role in early complications is still questioned. We retrieved from our medical files the data of all patients registered for LT and who had had a consultation with a physician specialized in substance abuse. Consumption of alcohol, tobacco, and drugs before and after registration for LT was assessed. One hundred and five patients were included. Pre-registration smoking and drinking rates were 75.3 and 69.5%, respectively. Forty-three patients continued smoking and nine continued drinking until LT. Mortality and early morbidity rates were not impacted by smoking or drinking. Active smokers had significantly increased prevalence of bacterial cholangitis in comparison to patients who stopped smoking when registered for LT. Persistent drinking in patients registered for LT is rare as compared to smoking; however, in our series, smoking until LT was not associated with major risk of early complication, except for cholangitis. This suggests that clinicians should take time to encourage patients to quit smoking and the intervention of a team specialized...Continue Reading

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Citations

May 23, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Alisa LikhitsupRobert J Fontana
Aug 26, 2017·World Journal of Hepatology·Hélène Donnadieu-RigoleGeorges-Philippe Pageaux
Aug 9, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·David T DulaneyRandeep Kashyap
Mar 20, 2018·Journal of Intensive Care Medicine·Justin K LuiScott E Kopec

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