Impact of Tobacco Versus Electronic Cigarette Smoking on Platelet Function

The American Journal of Cardiology
Cristina NocellaRoberto Carnevale

Abstract

Electronic cigarettes (E-cigarettes) have become popular as substitutes for conventional tobacco cigarettes or to aid quitting, but little is known about the potential risks to cardiovascular health for smokers and nonsmokers. We sought to compare the impact of E-cigarettes with conventional cigarettes on platelet function in healthy adult smokers and nonsmokers. A crossover single-blind study in 40 healthy participants (20 smokers, 20 nonsmokers, matched for age and sex) was conducted. Each participant smoked a conventional cigarette then returned 1 week later to vape a study E-cigarette with the same nominal nicotine content. Blood samples were drawn shortly before and 5 minutes after each episode and analyzed for platelet aggregation, soluble CD40-ligand (sCD40L) and soluble P-selectin (sP-selectin). At baseline, smokers had significantly higher levels of sCD40L and sP-selectin (all p ≤0.01) than nonsmokers. Within 5 minutes of using either a conventional cigarette or E-cigarette, changes in the levels of sCD40L, sP-selectin, and platelet aggregation (all p ≤0.01) were detectable in both smokers and nonsmokers. In smokers, there were no significant changes in sCD40L and sP-selectin but there was a significant increase in pla...Continue Reading

Citations

Feb 2, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Daniel J ConklinAruni Bhatnagar
Jan 15, 2020·European Cardiology·Domenico D'AmarioFilippo Crea
Jul 22, 2020·Journal of Cardiovascular Pharmacology and Therapeutics·Jean E Montes RamirezFatima Z Alshbool
Aug 29, 2020·Current Hypertension Reports·Jordan LynchDaniel J Conklin
Mar 17, 2019·Current Atherosclerosis Reports·Audrey Darville, Ellen J Hahn
Oct 1, 2020·JRSM Cardiovascular Disease·Jack StewartPeter Wilkinson
Aug 25, 2020·Current Emergency and Hospital Medicine Reports·Mariangela PeruzziFrancesco Versaci
Jun 12, 2020·European Heart Journal Supplements : Journal of the European Society of Cardiology·Giuseppe Biondi ZoccaiGiacomo Frati
Sep 27, 2019·Current Addiction Reports·Krysten W Bold, Suchitra Krishnan-Sarin
Nov 20, 2020·Journal of the American Heart Association·Neal L BenowitzPeyton Jacob
Oct 1, 2020·Minerva cardioangiologica·Marco LombardiSalvatore Carbone
Jul 26, 2019·Preventive Medicine·Ciaran D KennedyCharlotta Pisinger
Feb 13, 2021·Heart·Negeen ShahandehHolly R Middlekauff
Mar 12, 2021·Current Cardiology Reports·Saroj KhadkaTimir K Paul
Dec 19, 2020·The Canadian Journal of Cardiology·Arash Nayeri, Holly Middlekauff
Mar 23, 2021·Function·Robert TarranLoren E Wold
May 11, 2019·Trends in Cardiovascular Medicine·Holly R Middlekauff
Apr 29, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ignatios IkonomidisArgirios E Tsantes
May 11, 2021·Seminars in Thrombosis and Hemostasis·Melissa WhiteNeil A Goldenberg
Oct 21, 2020·Redox Biology·Juan WangCharles Ansong
May 20, 2021·Respiratory Research·Patrice MarquesMaria-Jesus Sanz
Jul 27, 2021·American Journal of Preventive Medicine·Clayton R Critcher, Michael Siegel
Sep 11, 2021·International Journal of Cardiology·Daniel MetzenAmin Polzin
Sep 24, 2021·Annual Review of Pharmacology and Toxicology·Terry GordonLung Chi Chen
Jan 19, 2022·Circulation·Evan W NeczyporRobert Tarran
Feb 1, 2022·Hospital Pediatrics·Gift KopsombutRyan Brogan

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