PMID: 18705576Aug 19, 2008Paper

Impact of total pancreatectomy with islet cell transplant on chronic pancreatitis management at a disease-based center

The American Surgeon
Jennifer DixonDavid B Adams

Abstract

Because of poor outcomes with traditional surgical management, total pancreatectomy with autologous islet transplantation (TPAIT) has been heralded as a breakthrough in the management of severe chronic pancreatitis intractable to medical management. To assess the impact of TPAIT on a pancreatobiliary disease-based center, a retrospective review and analysis of patients who underwent TPAIT after failing traditional surgical management was undertaken. Seven patients who underwent TPAIT were identified. Patient hospitalizations, emergency department visits, and clinic visits in the year pre- and post-TPAIT were tabulated. Average body weights and serum prealbumin were recorded during the year pre- and post-TPAIT. Based on the number of hospitalizations, clinic visits, and emergency department visits as an indicator of overall symptom severity, patients experienced an improvement in symptoms during the 12 months after TPAIT. Prealbumin values remained stable during the postoperative year. An observed decrease in weight suggests that other factors may be impacting the overall state of nutrition. The impact of TPAIT on the surgical management of chronic pancreatitis is limited in scope and benefit and continues to require careful ana...Continue Reading

References

Jan 1, 1990·World Journal of Surgery·H B GreenleeG V Aranha
Jan 1, 1986·American Journal of Surgery·P A GraceW P Longmire
Jun 1, 1995·The New England Journal of Medicine·M L SteerS Freedman
May 1, 1994·Annals of Surgery·D B AdamsM C Anderson
Aug 28, 1998·Gastroenterology·A L WarshawC Fernández-Del Castillo
Jan 1, 1997·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·M W BüchlerH G Beger
Sep 2, 1999·The Surgical Clinics of North America·J R IzbickiT Kuechler
Feb 17, 2001·Gastroenterology·B Etemad, D C Whitcomb
Feb 19, 2002·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·P A TrolliG Zuccaro
Jan 30, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Natalia LasztityMagda Antal
May 3, 2003·Lancet·R M S MitchellJ Baillie
Dec 17, 2003·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Horacio L Rodriguez RiloAndrew M Lowy
Mar 31, 2004·Journal of the American College of Surgeons·Rainer W G GruessnerAngelika C Gruessner
Mar 24, 2005·The American Journal of Gastroenterology·Deborah FitzsimmonsColin D Johnson
Nov 5, 2005·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Brian J BillingsMichael G Sarr
May 8, 2007·Journal of the American College of Surgeons·Thomas SchnelldorferDavid B Adams
Dec 7, 2007·The Surgical Clinics of North America·Juan J BlondetDavid E R Sutherland

❮ Previous
Next ❯

Citations

Dec 7, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Prathab Balaji SaravananBashoo Naziruddin
Apr 4, 2012·Cell Transplantation·Hongjun WangLeo E Otterbein
Jun 3, 2011·Journal of Diabetes·Shinichi Matsumoto
Jun 21, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Melena D BellinDavid E R Sutherland
Jan 6, 2012·Journal of Transplantation·Hongjun WangLeo E Otterbein
Mar 9, 2012·Journal of the American College of Surgeons·David E R SutherlandTimothy L Pruett

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.