Impact of TP53 codon 72 and MDM2 SNP 309 polymorphisms in pancreatic ductal adenocarcinoma

PloS One
Yasuki HoriTakashi Joh

Abstract

Single-nucleotide polymorphisms (SNPs) of TP53 (codon 72, rs1042522) and MDM2 promoter (SNP 309, rs2279744) have been associated with risk for various human cancers. However, studies analyzing these polymorphisms in pancreatic ductal adenocarcinoma (PDAC) are lacking. We investigated TP53 codon 72 and MDM2 SNP 309 polymorphisms in 32 patients with PDAC, 16 patients with chronic pancreatitis (CP), and 32 normal controls, using formalin-fixed paraffin-embedded tissue. We also examined TP53 and MDM2 protein immunohistochemistry (IHC) to assess the involvement of these differences in malignant transformation and disease progression. TP53 Pro/Pro genotype was significantly more frequent in PDAC patients than in controls (65.6 vs. 15.6%, p < 0.001) and no significant difference was found between CP patients (37.5%) and controls. In MDM2 SNP 309, there were no significant differences among the three groups. Based on the Kaplan-Meier analysis, overall survival was significantly shorter in MDM2 G/G genotypes compared with other genotypes (G/T and T/T) (359 vs. 911 days, p = 0.016) whereas no significant differences in TP53 genotypes were observed (638 vs. 752 days, p = 0.471). Although TP53 IHC was frequent in PDAC patients (53.1%), TP5...Continue Reading

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Citations

Nov 4, 2016·Medical Oncology·Jaroslav TumasAudrius Sileikis
May 5, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Yasuki HoriTakashi Joh
Apr 11, 2020·OncoTargets and Therapy·Chu WuYunlian Tang
Jan 9, 2018·Journal of Neurosurgical Sciences·Pier Paolo PancianiMarco Fontanella
Apr 17, 2021·Scientific Reports·Yasuki HoriHirotaka Ohara

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Methods Mentioned

BETA
surgical resection
PCR
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Assay

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