Abstract
Footpad dermatitis (FPD) is used in the poultry industry as an animal welfare criterion to determine stocking density. Trace minerals (TM) play a role in skin integrity and wound healing. This study evaluated the impact of TM on FPD and consisted of 3 treatments supplemented with 0 (NTM), low (LTM) and high (HTM) TM levels in the same basal diet. On d21, 71% birds in all treatments developed mild FPD and pens were top-dressed with dry litter to promote FPD healing. Compared to NTM, LTM reduced area under the curve (AUC) of FPD lesion scores during d21-42, HTM reduced the AUC of FPD lesion scores during d7-21 and d21-42. LTM improved growth performance on d14, HTM improved growth performance on d14 and d28. LTM and/or HTM increased gene expression of VEGF, TIMP3, TIMP4, MMP13, ITGA2, ITGA3 and CD40, which promoted collagen synthesis, deposition and organization; cell migration, matrix remodeling, and angiogenesis. LTM and/or HTM increased inflammation by upregulating TNFα and IL-1β during the early wound healing phase and reduced inflammation by downregulating IL-1β during the late wound healing phase. Our findings showed that TM not only improved growth performance but also reduced FPD development by promoting FPD wound healing.
References
Jan 1, 1977·Poultry Science·R H HarmsC F Simpson
Dec 1, 1988·The Journal of Cell Biology·E J MackieD Liverani
Apr 1, 1982·The Journal of Nutrition·W OpsahlR S Riggins
May 26, 1995·The Journal of Biological Chemistry·S FrankS Werner
Apr 4, 1997·Science·P Martin
Jul 3, 1998·British Poultry Science·G WangJ Svedberg
Apr 24, 1999·The British Journal of Dermatology·I TenaudB Dréno
Nov 7, 1999·Histochemistry and Cell Biology·M IwataT Matsumura
Jun 23, 2001·Circulation Research·S UemuraP S Tsao
Jul 24, 2002·Diabetologia·R LobmannH Lehnert
Oct 7, 2003·Journal of Translational Medicine·Francesco M Marincola
Apr 20, 2004·The International Journal of Biochemistry & Cell Biology·Ruth Chiquet-Ehrismann, Richard P Tucker
May 18, 2004·The Journal of Biological Chemistry·Johanna JokinenJyrki Heino
Jul 22, 2004·Experimental Dermatology·Nathalie ChebassierBrigitte Dréno
May 3, 2005·Journal of the American College of Cardiology·Gian Paolo FadiniAngelo Avogaro
Jul 30, 2005·Poultry Science·J L CampoI Muñoz
May 11, 2007·The American Journal of Clinical Nutrition·Mette M BergerLuc Tappy
Oct 24, 2007·British Poultry Science·R K MayneP M Hocking
Dec 18, 2007·The International Journal of Biochemistry & Cell Biology·Sean E Gill, William C Parks
Feb 26, 2008·Trends in Biotechnology·J Matthew RhettRobert G Gourdie
Apr 5, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·M MullerP Y Benhamou
Apr 1, 1984·Avian Pathology : Journal of the W.V.P.A·M F Martland
Jul 1, 1985·Avian Pathology : Journal of the W.V.P.A·M F Martland
Sep 21, 2010·Poultry Science·E M Shepherd, B D Fairchild
Jun 3, 2011·World Journal of Gastroenterology : WJG·Masahiro Iizuka, Shiho Konno
Apr 10, 2012·PloS One·Ashley W SeifertMalcolm Maden
Apr 25, 2012·Cell and Tissue Research·Vera L MartinsEdel A O'Toole
Mar 14, 2013·BioMed Research International·Fanxing XuDana T Graves
Dec 25, 2013·The Journal of Veterinary Medical Science·Kazuyo TairaKozo Takase
Feb 15, 2014·Advances in Wound Care·Andrew Leask
Feb 15, 2014·Advances in Wound Care·Stellar Boo, Lina Dagnino
Mar 4, 2014·Advances in Wound Care·William J EnnisAmelia Bartholomew
Oct 11, 2014·Advances in Wound Care·Kelly E Johnson, Traci A Wilgus
Mar 15, 2016·Frontiers in Cellular and Infection Microbiology·Juxing ChenJeffery Escobar