Impact of Trail Running Races on Blood Viscosity and Its Determinants: Effects of Distance

International Journal of Molecular Sciences
Mélanie RobertPhilippe Connes

Abstract

Blood rheology is a key determinant of tissue perfusion at rest and during exercise. The present study investigated the effects of race distance on hematological, blood rheological, and red blood cell (RBC) senescence parameters. Eleven runners participated in the Martigny-Combes à Chamonix 40 km race (MCC, elevation gain: 2300 m) and 12 others in the Ultra-Trail du Mont Blanc (UTMB, 171 km, elevation gain: 10,000 m). Blood samples were collected before and after the races. After the UTMB, the percentage of RBC phosphatidylserine (PS) exposure was not affected while RBC CD235a levels decreased and RBC-derived microparticles increased. In contrast, after the MCC, RBC PS exposure increased, while RBC CD235a and RBC-derived microparticles levels were not affected. The free hemoglobin and hemolysis rate did not change during the races. RBC aggregation and blood viscosity at moderate shear rates increased after the MCC. RBC deformability, blood viscosity at a high shear rate, and hematocrit decreased after the UTMB but not after the MCC. Our results indicate that blood rheology behavior is different between a 40 km and a 171 km mountain race. The low blood viscosity after the ultra-marathon might facilitate blood flow to the muscles...Continue Reading

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Citations

Apr 6, 2021·Clinical Hemorheology and Microcirculation·Sarah SkinnerPhilippe Connes
Jun 3, 2021·International Journal of Environmental Research and Public Health·Francisco PradasCarlos Castellar

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Methods Mentioned

BETA
rheology
contraception
flow cytometry
flow-cytometry
Assay

Software Mentioned

GraphPad Prism

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