Impact of Training Method on the Robustness of the Visual Assessment of 18F-Florbetaben PET Scans: Results from a Phase-3 Study

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
John SeibylOsama Sabri

Abstract

Training for accurate image interpretation is essential for the clinical use of β-amyloid PET imaging, but the role of interpreter training and the accuracy of the algorithm for routine visual assessment of florbetaben PET scans are unclear. The aim of this study was to test the robustness of the visual assessment method for florbetaben scans, comparing efficacy readouts across different interpreters and training methods and against a histopathology standard of truth (SoT). Analysis was based on data from an international open-label, nonrandomized, multicenter phase-3 study in patients with or without dementia (ClinicalTrials.gov: NCT01020838). Florbetaben scans were assessed visually and quantitatively, and results were compared with amyloid plaque scores. For visual assessment, either in-person training (n = 3 expert interpreters) or an electronic training method (n = 5 naïve interpreters) was used. Brain samples from participants who died during the study were used to determine the histopathologic SoT using Bielschowsky silver staining (BSS) and immunohistochemistry for β-amyloid plaques. Data were available from 82 patients who died and underwent postmortem histopathology. When visual assessment results were compared with B...Continue Reading

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Citations

Aug 31, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Keshav Anand, Marwan Sabbagh
Apr 22, 2017·Nihon Hoshasen Gijutsu Gakkai zasshi·Go AkamatsuMichio Senda
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