Impact of transmural heterogeneities on arterial adaptation: application to aneurysm formation

Biomechanics and Modeling in Mechanobiology
H SchmidM Itskov

Abstract

Recent experimental and computational studies have shown that transmurally heterogeneous material properties through the arterial wall are critical to understanding the heterogeneous expressions of constituent degrading molecules. Given that expression of such molecules is thought to be intimately linked to local magnitudes of stress, modelling the transmural stress distribution is critical to understanding arterial adaption during disease. The aim of this study was to develop an arterial growth and remodelling framework that can incorporate both transmurally heterogeneous constituent distributions and residual stresses, into a 3-D finite element model. As an illustrative example, we model the development of a fusiform aneurysm and investigate the effects of elastinous and collagenous heterogeneities on the stress distribution during evolution. It is observed that the adaptive processes of growth and remodelling exhibit transmural variations. For physiological heterogeneous constituent distributions, a stress peak appears in the media towards the intima, and a stress plateau occurs towards the adventitia. These features can be primarily attributed to the underlying heterogeneity of elastinous constituents. During arterial adapt...Continue Reading

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Citations

May 25, 2010·Biomechanics and Modeling in Mechanobiology·P N WattonY Ventikos
Feb 25, 2011·Computer Methods in Biomechanics and Biomedical Engineering·H SchmidM Itskov
Dec 14, 2011·Computer Methods in Biomechanics and Biomedical Engineering·H SchmidM Itskov
May 29, 2013·International Journal for Numerical Methods in Biomedical Engineering·A ValentínG A Holzapfel
Jan 16, 2014·International Journal for Numerical Methods in Biomedical Engineering·P AparícioP N Watton
Feb 1, 2015·Biomechanics and Modeling in Mechanobiology·K Y Volokh
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Dec 5, 2014·Journal of Biomechanical Engineering·Andrii GrytsanGerhard A Holzapfel
Aug 19, 2015·Journal of Biomechanics·Kerianne E SteuckePatrick W Alford

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