Impact of transplant nephrectomy on peak PRA levels and outcome after kidney re-transplantation

World Journal of Transplantation
Dietlind Tittelbach-HelmrichOliver Drognitz

Abstract

To determine the impact of transplant nephrectomy on peak panel reactive antibody (PRA) levels, patient and graft survival in kidney re-transplants. From 1969 to 2006, a total of 609 kidney re-transplantations were performed at the University of Freiburg and the Campus Benjamin Franklin of the University of Berlin. Patients with PRA levels above (5%) before first kidney transplantation were excluded from further analysis (n = 304). Patients with graft nephrectomy (n = 245, NE+) were retrospectively compared to 60 kidney re-transplants without prior graft nephrectomy (NE-). Peak PRA levels between the first and the second transplantation were higher in patients undergoing graft nephrectomy (P = 0.098), whereas the last PRA levels before the second kidney transplantation did not differ between the groups. Age adjusted survival for the second kidney graft, censored for death with functioning graft, were comparable in both groups. Waiting time between first and second transplantation did not influence the graft survival significantly in the group that underwent nephrectomy. In contrast, patients without nephrectomy experienced better graft survival rates when re-transplantation was performed within one year after graft loss (P = 0....Continue Reading

References

Feb 15, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jinwen LinJianghua Chen
Sep 16, 2015·Current Opinion in Nephrology and Hypertension·Song Ching Ong, Robert S Gaston
Oct 31, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Kim Lw BunthofLuuk B Hilbrands
Aug 28, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Kim Lw BunthofLuuk B Hilbrands

Related Concepts

Cessation of Life
Nephrectomy
Graft Survival
Kidney
Graft Loss
Transplantation
Grafting Procedure
Adjustment Disorders
Analysis
Transplantation Aspects

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