Impact of treadmill running and sex on hippocampal neurogenesis in the mouse model of amyotrophic lateral sclerosis.

PloS One
Xiaoxing MaMark A Tarnopolsky

Abstract

Hippocampal neurogenesis in the subgranular zone (SGZ) of dentate gyrus (DG) occurs throughout life and is regulated by pathological and physiological processes. The role of oxidative stress in hippocampal neurogenesis and its response to exercise or neurodegenerative diseases remains controversial. The present study was designed to investigate the impact of oxidative stress, treadmill exercise and sex on hippocampal neurogenesis in a murine model of heightened oxidative stress (G93A mice). G93A and wild type (WT) mice were randomized to a treadmill running (EX) or a sedentary (SED) group for 1 or 4 wk. Immunohistochemistry was used to detect bromodeoxyuridine (BrdU) labeled proliferating cells, surviving cells, and their phenotype, as well as for determination of oxidative stress (3-NT; 8-OHdG). BDNF and IGF1 mRNA expression was assessed by in situ hybridization. Results showed that: (1) G93A-SED mice had greater hippocampal neurogenesis, BDNF mRNA, and 3-NT, as compared to WT-SED mice. (2) Treadmill running promoted hippocampal neurogenesis and BDNF mRNA content and lowered DNA oxidative damage (8-OHdG) in WT mice. (3) Male G93A mice showed significantly higher cell proliferation but a lower level of survival vs. female G93A ...Continue Reading

References

Jan 1, 1991·Neuroepidemiology·A ChióD Schiffer
Nov 1, 1994·Endocrinology·R R Reinhardt, C A Bondy
Apr 1, 1995·Pharmacology, Biochemistry, and Behavior·S M SomaniL P Rybak
Jan 1, 1994·Journal of Neural Transmission. General Section·A AdemV Sara
Sep 26, 1997·The Journal of Comparative Neurology·G J Popken, P B Farel
Oct 31, 1998·Brain Research. Molecular Brain Research·H S OliffC W Cotman
May 8, 1999·Scientific American·G Kempermann, F H Gage
Oct 12, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A Russo-NeustadtC W Cotman
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·A KlunglandD E Barnes
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·H van PraagF H Gage
Jan 29, 2000·Brain Research. Molecular Brain Research·S LinnarssonP Ernfors
Mar 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·O MinowaT Noda
Jun 7, 2000·Proceedings of the National Academy of Sciences of the United States of America·A J EischE J Nestler
Mar 17, 2001·Nature Reviews. Neuroscience·C G Gross
Apr 20, 2001·Brain Research. Molecular Brain Research·H WaritaK Abe
Jun 15, 2001·The Journal of Comparative Neurology·H A Cameron, R D McKay
Apr 12, 2002·Brain Research. Developmental Brain Research·Michelle F AndersonPeter S Eriksson
Jun 28, 2002·Trends in Neurosciences·Carl W Cotman, Nicole C Berchtold
Nov 15, 2002·Transplantation Proceedings·Y H KimK C Mun
Apr 30, 2003·The Journal of Comparative Neurology·Alexandre G DayerHeather A Cameron

❮ Previous
Next ❯

Citations

Feb 2, 2016·Free Radical Biology & Medicine·Zsolt RadakErika Koltai
Apr 15, 2015·Physiology & Behavior·Mohammad Esmaiel AfzalpourHossein Abtahi Eivari
Jul 1, 2015·Hormones and Behavior·Paula Duarte-GutermanLiisa A M Galea
Apr 10, 2017·Behavioural Brain Research·Dilek ÖzbeyliÖzgür Kasımay Çakır
Jan 6, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Takeshi NishijimaIchiro Kita
Jan 25, 2020·Journal of Neural Transmission·Aline SiteneskiAna Lúcia S Rodrigues

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
PCR
light microscopy
optical
dissector
confocal microscopy
X-ray

Software Mentioned

Pro
Statistica
NIH Image
Image

Related Concepts

Related Feeds

ALS: Stress Granules

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. TDP-43 is an ALS-linked protein that is known to regulate splicing and storage of specific mRNAs into stress granules, which have been implicated in formation of ALS protein aggregates. Here is the latest research in this field.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

ALS: Phenotypes

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized phenotypically by progressive muscle weakness. Clinical phenotypes of ALS can be classified based on the pattern, level, and area of onset (e.g. bulbar, cervical, lumbar). Here is the latest research investigating phenotypes of ALS.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating genetic alterations in this genetically heterogeneous disorder.

ALS: Genetics

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Astrocytes & Huntington’s Disease

Astrocytes are abundant within the central nervous system and their dysfunction has been thought to be an important contributor to some neurodegenerative diseases, in particular Huntington’s disease. Damage to these cells may make neurons more susceptible to degeneration. Here is the latest research on astrocytes and Huntington’s disease.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

Astrocytes & Huntington’s Disease (MDS)

Astrocytes are abundant within the central nervous system and their dysfunction has been thought to be an important contributor to some neurodegenerative diseases, in particular Huntington’s disease. Damage to these cells may make neurons more susceptible to degeneration. Here is the latest research on astrocytes and Huntington’s disease.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.