Impact of treatment on cellular immunophenotype in MS: A cross-sectional study.

Neurology. Neuroimmunology and Neuroinflammation
Maria CellerinoAntonio Uccelli

Abstract

To establish cytometry profiles associated with disease stages and immunotherapy in MS. Demographic/clinical data and peripheral blood samples were collected from 227 patients with MS and 82 sex- and age-matched healthy controls (HCs) enrolled in a cross-sectional study at 4 European MS centers (Spain, Italy, Germany, and Norway). Flow cytometry of isolated peripheral blood mononuclear cells was performed in each center using specifically prepared antibody-cocktail Lyotubes; data analysis was centralized at the Genoa center. Differences in immune cell subsets were assessed between groups of untreated patients with relapsing-remitting or progressive MS (RRMS or PMS) and HCs and between groups of patients with RRMS taking 6 commonly used disease-modifying drugs. In untreated patients with MS, significantly higher frequencies of Th17 cells in the RRMS population compared with HC and lower frequencies of B-memory/B-regulatory cells as well as higher percentages of B-mature cells in patients with PMS compared with HCs emerged. Overall, the greatest deviation in immunophenotype in MS was observed by treatment rather than disease course, with the strongest impact found in fingolimod-treated patients. Fingolimod induced a decrease in t...Continue Reading

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Citations

Aug 25, 2020·Annals of Clinical and Translational Neurology·Priscilla Bäcker-KoduahAlexander Ulrich Brandt
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Methods Mentioned

BETA
flow cytometry

Software Mentioned

R
GraphPad Prism
MultipleMS
SPSS

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