Impact of treatment on the short-term prognosis of status epilepticus in two population-based cohorts.

Journal of Neurology
L VignatelliRoberto D'Alessandro

Abstract

Epidemiological surveys on status epilepticus (SE) in adults in two Italian areas (Bologna and Lugo di Romagna) disclosed a major difference in 30-day case fatality (33% versus 7 %). Since suboptimal management was hypothesised in the first site, we compared the quality of treatment in the two cohorts and examined its contribution to prognosis. The Bologna and Lugo di Romagna cohorts of adults with incident SE were included. Patients with post-anoxic encephalopathy were excluded. Quality of treatment was independently classified by two experts. Clinical and treatment features were compared in the two sites. The contribution of variables collected to the 30-day case fatality was explored through multivariate logistic analysis in the whole group of patients. Fifty-seven patients were included. No differences were observed between Bologna and Lugo di Romagna either in clinical features or the time of management. The quality of global drug treatment significantly differed in disfavour of Bologna (p = 0.044). Independent predictors of a worse 30-day case fatality in the whole group of patients were the onset of SE in hospital (OR 9.67, p = 0.0095) and the poor global quality of treatment (partially correct versus correct OR 3.59, p ...Continue Reading

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Citations

Aug 18, 2012·Journal of Neurology·Andrea O RossettiBernard Burnand
Oct 16, 2012·Neurocritical Care·Matthew FergusonM Brandon Westover
Jul 19, 2011·Epilepsia·Florence Canouï-PoitrineElena Paillaud
Feb 24, 2009·Revue neurologique·A-O Rossetti
Jan 31, 2012·Neurologic Clinics·Brandon Foreman, Lawrence J Hirsch
Sep 24, 2011·Lancet Neurology·Andrea O Rossetti, Daniel H Lowenstein
Aug 10, 2011·Epilepsy & Behavior : E&B·Susan T HermanFrank W Drislane
May 9, 2015·Epilepsy & Behavior : E&B·M FerlisiUNKNOWN International Steering Committee of the StEp Audit
Aug 28, 2015·Drugs·Eugen TrinkaFrancesco Brigo
Sep 9, 2015·Epilepsy Research and Treatment·Leena KämppiSeppo Soinila
Sep 11, 2013·Epilepsy Research·Kristin RantschJohannes Rösche
Aug 16, 2011·Epilepsy & Behavior : E&B·Frank W DrislaneDonald L Schomer
Mar 23, 2021·Der Nervenarzt·F RosenowUNKNOWN Österreichische Gesellschaft für Neurologie (ÖGN)

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