Impact of tumor microenvironment composition on therapeutic responses and clinical outcomes in cancer

Future Oncology
Fern AnariMatthew Zibelman

Abstract

The tumor microenvironment (TME) plays an important role in cancer growth and progression. Paradoxically, the TME is capable of acting as both a potential barrier and facilitator of tumor proliferation by affecting various processes including local growth resistance, immune system interactions, and the formation of distant metastases. This important interaction between cancer cells and their local environment, composed of immune cells, angiogenic cells, lymphatic endothelial cells and cancer-associated fibroblasts is paramount to determine a cancer cell's ability to grow and ultimately metastasize. It is essential to understand this complex interplay in order to define treatment modalities to target the TME as part of anti-cancer therapy.

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Mar 16, 2019·International Journal of Cancer. Journal International Du Cancer·Ziqian LiJun Du
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Methods Mentioned

BETA
surgical resection
biopsies
biopsy
flow cytometry

Clinical Trials Mentioned

NCT02178722
NCT02752074
NCT02327078
NCT02614456
NCT02964078
NCT02853331
NCT02420821
NCT03074513
NCT02982694
NCT03175432

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