Impact of urban environmental exposures on cognitive performance and brain structure of healthy individuals at risk for Alzheimer's dementia

Environment International
Marta Crous-BouALFA Study

Abstract

Air quality might contribute to incidence of dementia-related disorders, including Alzheimer's dementia (AD). The aim of our study is to evaluate the effect of urban environmental exposures (including exposure to air pollution, noise and green space) on cognitive performance and brain structure of cognitively unimpaired individuals at risk for AD. The ALFA (ALzheimer and FAmilies) study is a prospective cohort of middle-age, cognitively unimpaired subjects, many of them offspring of AD patients. Cognitive performance was measured by the administration of episodic memory and executive function tests (N = 958). Structural brain imaging was performed in a subsample of participants to obtain morphological information of brain areas, specially focused on cortical thickness, known to be affected by AD (N = 228). Land Use Regression models were used to estimate residential exposure to air pollutants. The daily average noise level at the street nearest to each participant's residential address was obtained from noise maps. For each participant residential green exposure indicators, such as surrounding greenness or amount of green, were generated. General linear models were conducted to assess the association between environmental expos...Continue Reading

Citations

Jun 23, 2020·Journal of Alzheimer's Disease : JAD·Luigi Attademo, Francesco Bernardini
Mar 15, 2021·The Science of the Total Environment·Kyung-Duk MinSun-Young Kim
Aug 25, 2021·Environment International·Yimeng SongYongze Song
Aug 13, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Diana YounanJiu-Chiuan Chen
Oct 15, 2021·Environment International·Rhiannon ThompsonMireille B Toledano

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