Impact of using different blood donor subpopulations and models on the estimation of transfusion transmission residual risk of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus in Zimbabwe

Transfusion
Tonderai MapakoMarinus van Hulst

Abstract

Various models for estimating the residual risk (RR) of transmission of infections by blood transfusion have been published mainly based on data from high-income countries. However, to obtain the data required for such an assessment remains challenging for most developing settings. The National Blood Service Zimbabwe (NBSZ) adapted a published incidence-window period (IWP) model, which has less demanding data requirements. In this study we assess the impact of various definitions of blood donor subpopulations and models on RR estimates. We compared the outcomes of two published models and an adapted NBSZ model. The Schreiber IWP model (Model 1), an amended version (Model 2), and an adapted NBSZ model (Model 3) were applied. Variably the three models include prevalence, incidence, preseroconversion intervals, mean lifetime risk, and person-years at risk. Annual mean RR estimates and 95% confidence intervals for each of the three models for human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) were determined using NBSZ blood donor data from 2002 through 2011. The annual mean RR estimates for Models 1 through 3 were 1 in 6542, 5805, and 6418, respectively for HIV; 1 in 1978, 2027, and 1628 for H...Continue Reading

References

Jun 27, 1996·The New England Journal of Medicine·G B SchreiberJ J Korelitz
Sep 28, 1996·BMJ : British Medical Journal·K C Calman
Oct 19, 2002·Transfusion·Simone A GlynnUNKNOWN NHLBI Retrovirus Epidemiology Donor Study
Nov 9, 2002·Transfusion·Clive R SeedUNKNOWN Virology Subcommittee of the National Donor and Product Safety Committee, Australian Red Cross Blood Service
Jun 24, 2004·Vox Sanguinis·J P AuBuchon
Feb 8, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Erich V de PaulaFernando L Gonçales
Aug 22, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Hendriek C Boshuizen, Pieter H M van Baal
Oct 22, 2009·Transfusion·Sudha JayaramanIan Roberts
Oct 11, 2011·Transfusion·Ester C SabinoUNKNOWN NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II), International Component
Nov 2, 2012·Transfusion·Welling OeiMirjam E E Kretzschmar
Jan 25, 2014·Transfusion·Welling OeiMart P Janssen
Sep 14, 2014·Carbohydrate Research·Carlos A Stortz

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Citations

Jun 15, 2016·Transfusion·Anne F Eder
Mar 9, 2018·Frontiers in Medicine·Daniel Candotti, Syria Laperche
Jan 31, 2021·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·D CandottiS Laperche
Apr 3, 2021·Journal of Viral Hepatitis·Blessing DzingiraiNyashadzaishe Mafirakureva

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