Impact of valvuloarterial impedance on left ventricular longitudinal deformation in patients with aortic valve stenosis and preserved ejection fraction

Archives of Cardiovascular Diseases
Sylvestre MaréchauxPierre Vladimir Ennezat

Abstract

Left ventricular (LV) longitudinal deformation is a good marker of intrinsic myocardial dysfunction in pressure overload cardiomyopathies. To assess the effect of valvuloarterial haemodynamic load on LV longitudinal deformation in patients with aortic valve stenosis (AVS) and preserved LV ejection fraction (LVEF). Global LV longitudinal strain (GLS) was measured using speckle tracking imaging in a series of 82 consecutive patients with AVS (mean age 75+/-10 years; 50% men). The global (valvular+arterial) haemodynamic load imposed on the LV was estimated by the valvuloarterial impedance (Z(va)), and was calculated using either arm-cuff systolic peripheral blood pressure or systolic central aortic blood pressure estimated by SphygmoCor. Among this series of 82 patients with preserved LVEF, 79% had reduced LV GLS (<-18%). LV GLS correlated weakly with AVS severity, systemic vascular resistance and systemic arterial compliance. However, there was a good inverse correlation between increase in Z(va) and impairment of LV GLS (r=0.41 p<0.0001). On multivariable analysis, impaired GLS was associated with increased Z(va) (p<0.0001), increased E/Ea ratio (p=0.001) and increased LV end-diastolic volume index (p=0.021), while indices of va...Continue Reading

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Citations

Jan 17, 2012·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Cristina GianniniVitantonio Di Bello
Oct 4, 2011·Journal of Cardiac Failure·Sylvestre MaréchauxUNKNOWN Lille HFpEF Study Group
Mar 31, 2012·International Journal of Cardiology·Nicolas AmabileChristophe Caussin
Aug 12, 2014·Echocardiography·Yonghoon RimHyunggun Kim
Oct 14, 2017·European Heart Journal Cardiovascular Imaging·Geoffrey D HuntleyVuyisile T Nkomo
May 5, 2016·Journal of the American Heart Association·Sylvestre MaréchauxChristophe Tribouilloy
Oct 22, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Tiziana Claudia Aranzulla, Giuseppe Musumeci
Aug 7, 2021·Atherosclerosis·Vasiliki GardikiotiCharalambos Vlachopoulos

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