Impact of vancomycin MIC creep on patients with methicillin-resistant Staphylococcus aureus bacteremia

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
Yen-Cheng YehJung-Chung Lin

Abstract

To date, vancomycin is still the standard treatment for methicillin-resistant Staphylococcus aureus (MRSA) infections, but minimum inhibitory concentration (MIC) creep is becoming a major concern. The aims of this study were to investigate trends in vancomycin use and MIC values over the last decade at our institute and to evaluate the outcomes of bacteremic patients infected with MRSA isolates with reduced vancomycin susceptibility. Vancomycin use and density were evaluated using the defined daily doses (DDD) method. Patients with MRSA bacteremia were enrolled retrospectively. Patient demographic data and clinical outcomes were analyzed. The first isolate from each patient was collected for E-testing in order to determine vancomycin MIC. MIC trends were assessed as MIC(50), MIC(90), and the geometric mean. Vancomycin use has increased over the last decade. One hundred and forty patients were enrolled and their respective isolates were retrieved, including isolates from 45 patients in 2001, 46 patients in 2005, and 49 patients in 2009. The geometric mean (± standard deviation) of the vancomycin MIC for MRSA isolates obtained in 2009 was 1.39 ± 0.30 μg/mL, which is significantly higher than the mean vancomycin MIC obtained in 20...Continue Reading

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Citations

Mar 21, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sebastiaan J van Hal, Vance G Fowler
Oct 12, 2015·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Po-Chang LinYhu-Chering Huang
Oct 1, 2013·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Cheng Len SyYao-Shen Chen
Sep 19, 2014·The American Journal of the Medical Sciences·Justin B UseryTimothy H Self
Dec 3, 2014·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Soon-Hian TehMao-Wang Ho
Apr 30, 2013·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chung-Hao Huang, Yen-Hsu Chen
Oct 27, 2015·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Cheng-Pin ChenZhi-Yuan Shi
Sep 6, 2015·Diagnostic Microbiology and Infectious Disease·Matthaios Papadimitriou-OlivgerisIris Spiliopoulou
Jul 6, 2015·International Journal of Antimicrobial Agents·Stefania StefaniGiovanni Pacini
Feb 27, 2018·Expert Opinion on Pharmacotherapy·A KhanI M Gould
Feb 12, 2014·Antimicrobial Agents and Chemotherapy·Antonio Di GraziaMaria Luisa Mangoni
May 21, 2019·Expert Opinion on Drug Safety·Matteo BassettiDaniele Roberto Giacobbe
Aug 19, 2020·Animals : an Open Access Journal From MDPI·Alec MichaelMaurice Pitesky
Feb 12, 2021·Annals of Clinical Microbiology and Antimicrobials·Nathalia Bibiana TeixeiraMaria de Lourdes Ribeiro de Souza da Cunha
May 19, 2021·Journal of Dairy Science·S McDougallD Dymock

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