Impact of various body weights and serum creatinine concentrations on the bias and accuracy of the Cockcroft-Gault equation

Pharmacotherapy
Mary A WinterGina M Berg

Abstract

To evaluate the impact of various body weights and serum creatinine (S(c) (r) ) concentrations on the bias and accuracy of the Cockcroft-Gault creatinine clearance (C-G Cl(c) (r) ) equation compared with measured 24-hour Cl(c) (r) . Retrospective analysis. Tertiary care hospital. A total of 3678 patients with stable renal function and who underwent a 24-hour urine collection between July 1, 1996, and June 30, 2010. For each patient, C-G Cl(c) (r) was calculated and compared with a measured 24-hour Cl(c) (r) . Body weight adjustments to the calculation were performed based on the following weight classifications: underweight, normal weight, overweight, obese, and morbidly obese. In addition, C-G Cl(c) (r) was calculated by using rounded S(c) (r) values based on two S(c) (r) thresholds-0.8 mg/dl and 1 mg/dl-for patients with measured S(c) (r) values below those thresholds. Those patients were then evaluated after stratification into two age groups: all ages and a subgroup of patients aged 65 years or older. The S(c) (r) -rounded C-G Cl(c) (r) values were compared with the C-G Cl(c) (r) values using actual S(c) (r) values. Mean differences were calculated, and accuracy was evaluated. Use of actual body weight in the calculations f...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
May 1, 1992·The Annals of Pharmacotherapy·M B O'ConnellS D Bannick-Mohrland
May 1, 1988·Journal of the American Geriatrics Society·G L DrusanoJ W Warren
Jun 1, 1988·The American Journal of Medicine·D E Salazar, G B Corcoran
Oct 1, 1993·Critical Care Medicine·S RobertF Dumler
Jun 26, 1999·British Journal of Clinical Pharmacology·C M KirkpatrickE J Begg
Jul 17, 2004·British Journal of Clinical Pharmacology·Bruce Green, Stephen B Duffull
Sep 24, 2005·Clinical Pharmacokinetics·Sarayut JanmahasatianBruce Green
Jul 11, 2006·Annals of Clinical Biochemistry·Mohamed SaleemWolfram W W Woltersdorf
Nov 8, 2008·Cancer Chemotherapy and Pharmacology·Corine EkhartAlwin D R Huitema
Mar 21, 2009·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jasmina A DemirovicManjunath P Pai
Feb 6, 2010·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Tam KhuuPeter J Ambrose
Jul 27, 2010·Pharmacotherapy·Thomas C DowlingGilbert J Burckart
Aug 24, 2010·Advances in Chronic Kidney Disease·Manjunath P Pai

❮ Previous
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Citations

Jun 17, 2014·Clinical Therapeutics·Sara E RostasMichael S Calderwood
Jul 16, 2013·Therapeutic Drug Monitoring·Daniel L BrownAndrew J Masselink
Nov 5, 2015·British Journal of Clinical Pharmacology·Antoine BouquegneauPierre Delanaye
Jul 8, 2015·Proceedings of the National Academy of Sciences of the United States of America·Daniel W BelskyTerrie E Moffitt
Dec 31, 2015·Open Forum Infectious Diseases·David W KubiakMichael S Calderwood
Aug 15, 2015·The Annals of Thoracic Surgery·J Trent MagruderGlenn J Whitman
Sep 10, 2013·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M A Posadas SalasB Thomas
Nov 26, 2015·Pharmacotherapy·Young R LeeAustin Ballew
Jul 16, 2015·International Journal of Clinical Pharmacy·Fazlollah Keshavarzi
Jun 26, 2015·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Matthew ZuckermanKavita M Babu
Jan 13, 2015·Aging Clinical and Experimental Research·Andrea UngarNiccolò Marchionni
Apr 23, 2015·Journal of Palliative Medicine·Ewa Deskur-SmieleckaKatarzyna Wieczorowska-Tobis
Apr 9, 2015·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Janice RichardsonE Paul O'Donnell
Apr 5, 2016·Expert Review of Hematology·Enrico MaffiniBenedetto Bruno
Nov 8, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Dieter Kaag
Oct 21, 2016·Journal of Clinical Pharmacy and Therapeutics·N P Fewel
Nov 12, 2016·The Journal of Thoracic and Cardiovascular Surgery·J Trent MagruderViachaslau Barodka
Nov 22, 2013·The Annals of Pharmacotherapy·John W Ahern, Carl J Possidente
Mar 9, 2017·Journal of Thrombosis and Thrombolysis·Emmeline TranNicole Bohm
Jan 31, 2017·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Erin FrazeeNelson Leung
May 9, 2014·Expert Review of Anti-infective Therapy·Kenna D Payne, Ronald G Hall
Apr 5, 2017·BMC Nephrology·Linda Awdishu, Ravindra L Mehta
May 7, 2015·European Heart Journal. Acute Cardiovascular Care·Biljana StojcevskiUNKNOWN on the behalf of GREAT network
Sep 5, 2017·Pharmacotherapy·Lina MengStan C Deresinski
Aug 5, 2017·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Brian C CrandellTatjana Grgic
Nov 7, 2017·Journal of Pharmacy Practice·Emily A HigdonJoanna Q Hudson
Mar 18, 2017·American Journal of Therapeutics·Timothy NguyenShpres Cekaj
Sep 5, 2018·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Cristina Cuesta GruesoMaría S Díaz Carrasco
Jul 10, 2018·Journal of Cardiovascular Pharmacology·Stephen Y WangAaron V Kaplan
Mar 25, 2015·Antimicrobial Agents and Chemotherapy·Rujipas SirijatuphatVisanu Thamlikitkul
Jun 28, 2014·Stroke; a Journal of Cerebral Circulation·Scott Kaatz, Charles E Mahan
Sep 18, 2018·Pharmacology Research & Perspectives·Ajith M DissanayakeChristopher J Hood
Dec 18, 2018·Current Medical Research and Opinion·Wubshet H TesfayeSyed Tabish R Zaidi
Sep 28, 2017·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·David E NixBrian L Erstad
Feb 19, 2014·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jeremiah JosonRushabh Shah
Sep 9, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·David J Snyder, F Bahar Matusik
Feb 22, 2017·World Journal of Hepatology·Gianni B Scappaticci, Randolph E Regal
Nov 26, 2019·The Annals of Pharmacotherapy·Alison K LewGregory Eschenauer
Jan 21, 2020·Pharmacotherapy·Anne M MasichMathangi Gopalakrishnan
Feb 2, 2020·American Journal of Hypertension·Matthew K ArmstrongJames E Sharman
May 16, 2020·The Annals of Pharmacotherapy·Sean M McConachieDmitriy M Martirosov

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