Impact of vasopressin on hemodynamic and metabolic function in the decompensatory phase of hemorrhagic shock

Journal of Cardiothoracic and Vascular Anesthesia
Ken B JohnsonMark Cluff

Abstract

To explore how the potent vasoconstrictive features of vasopressin impact the rate of cardiovascular collapse and metabolic derangements associated with prolonged hemorrhagic shock. A prospective randomized trial. University hospital-based animal laboratory. Sixteen swine. Swine were bled in an isobaric fashion to achieve a linear decrease in the mean arterial blood pressure to 40 mmHg. The mean arterial blood pressure was then maintained at 40 mmHg until the onset of cardiovascular decompensation, defined as the need to reinfuse shed blood to maintain the blood pressure at 40 mmHg. Once at the onset of cardiovascular decompensation, animals were randomly assigned to 2 resuscitation groups: the crystalloid group received lactated Ringer's solution and the vasopressin group received lactated Ringer's solution and arginine vasopressin. Resuscitation consisted of infusing lactated Ringer's solution with and without vasopressin (0.05 U/kg/min) to maintain a blood pressure of 70 mmHg for 60 minutes. The rate of crystalloid infusion was compared between groups using an unpaired 2-tailed t test. Metabolic and hemodynamic parameters between groups over time were compared with a repeated measures analysis of variance. Vasopressin decrea...Continue Reading

References

Dec 1, 1986·Annals of Emergency Medicine·R F BellamyB A Wenger
Aug 29, 2000·Anesthesia and Analgesia·W G VoelckelV Wenzel
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael BucherArmin Kurtz
Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard MoreauDidier Lebrec

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Citations

May 24, 2013·Annals of Intensive Care·François BelonclePierre Asfar
Feb 23, 2008·Critical Care : the Official Journal of the Critical Care Forum·Stig MüllerTruls Myrmel
Jan 28, 2016·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·D T Martin, M A Schreiber
Dec 17, 2010·World Journal of Surgery·Stephen M CohnJoel E Michalek
Dec 1, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Natalie F Holt, Kenneth L Haspel
Aug 8, 2008·Best Practice & Research. Clinical Anaesthesiology·Volker WenzelMartin W Dünser
Apr 12, 2008·The Veterinary Clinics of North America. Small Animal Practice·Garret E Pachtinger, Kenneth Drobatz
Sep 26, 2014·BioMed Research International·Andrea Pasquale CossuGabriele Finco
Jun 30, 2007·Current Opinion in Critical Care·Juan A Oliver, Donald W Landry
Mar 9, 2018·World Journal of Emergency Surgery : WJES·Roberto BiniPaolo Cotogni
Jul 19, 2017·American Journal of Surgery·Carrie A SimsPatrick Reilly

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