Impact of vitamin C supplementation on post-cardiac surgery ICU and hospital length of stay

Anesthesiology and Pain Medicine
Anita SadeghpourBehshid Ghadrdoost

Abstract

Prolonged intensive care unit (ICU) and hospital stay after cardiac surgery is vitally important and is influenced by both intraoperative and postoperative factors. This randomized clinical trial study was designed to assess whether vitamin C supplementation could reduce the length of ICU and hospital stay in post-cardiac surgery patients. Two hundred and ninety patients scheduled for adult cardiac surgery including coronary, valve and congenital operations were randomized into two groups: an intervention group, who received 2 g of vitamin C (ascorbic acid) intravenously, immediately before surgery in the operating theatre, followed by 1 g daily oral doses for the first 4 postoperative days; and a placebo group, who received an equal number of identical tablets in the same shape and size. Hospital length of stay was significantly different between the two groups (10.17 ± 4.63 days in the intervention group vs. 12 ± 4.51 days in the placebo group; P = 0.01), while there was no significant difference in the ICU stay between the groups (3.42 ± 1.06 days in intervention group vs. 3.43 ± 1.09 days in the placebo group; P = 0.88). There were significant differences in the intubation time and the drainage volume in the ICU and the fir...Continue Reading

References

Feb 21, 2006·The Annals of Thoracic Surgery·Ortrud Vargas HeinClaudia Spies
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Nov 12, 2013·Journal of Cardiothoracic Surgery·Liu JianYuan Zhongxiang

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Citations

Aug 2, 2016·Advanced Pharmaceutical Bulletin·Evangelos PolymeropoulosIoannis Τoumpoulis
Jan 14, 2016·Seminars in Cardiothoracic and Vascular Anesthesia·Adam S EvansJacob T Gutsche
Jul 4, 2018·Internal Medicine Journal·Yogesh SharmaCampbell Thompson
Nov 4, 2016·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·William L Baker, Craig I Coleman
Dec 13, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Jake T B CollieRinaldo Bellomo
Jun 18, 2016·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·W A C Kristine Koekkoek, Arthur R H van Zanten
Dec 12, 2018·Anesthesiology and Pain Medicine·Ziae TotonchiMohammad Hassan Ghaffarinejad
Mar 31, 2017·Therapeutic Advances in Infectious Disease·Célia F Rodrigues, Mariana Henriques
Apr 3, 2019·Nutrients·Harri Hemilä, Elizabeth Chalker
Oct 27, 2018·SAGE Open Medicine·Michael Zhang, David F Jativa

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

SPSS

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