Impact of vitamin D status and obesity on C-reactive protein in kidney-transplant patients

Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation
Bettina EwersPeter Marckmann

Abstract

We examined whether vitamin D status and obesity are associated with low-grade systemic inflammation, as assessed by serum concentrations of C-reactive protein (CRP) in an adult population of kidney-transplant patients. This was a single-center, cross-sectional study. Data were collected between December 2005 and April 2006 from 161 adult (aged >18 years) kidney-transplant patients (mean age, 53.1 years; SD, 11.5 years; females/males, 78/83), with a median kidney-graft age of 7.0 years and serum CRP levels < or =10 mg/L. Vitamin D status was assessed by serum concentrations of 25-hydroxyvitamin D (25-OHD) and 1,25-dihydroxyvitamin D (1,25(OH)(2)D). The presence of low-grade systemic inflammation was assessed by serum CRP. Selected lifestyle factors and anthropometric variables were determined in a subgroup of patients (n = 90). Bivariate correlation and multiple regression analyses were performed. Hypovitaminosis D (ie, S-25-OHD < or =75 nmol/L) was present in 73% of females, and 89% of males. The median level of serum CRP was 1.7 mg/L. Vitamin D status was not significantly associated with serum CRP. In the patient subgroup, indices of obesity (body mass index, body weight, and fat mass) correlated positively, and lean body ma...Continue Reading

References

Aug 27, 1997·Transplantation·C S ModlinA C Novick
May 6, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F CaravacaM C García
May 22, 1998·Transplantation Proceedings·I IşiklarE A Niron
Oct 24, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A FestaS M Haffner
Mar 13, 2003·Kidney International·Erik M StuvelingDick De Zeeuw
Jun 28, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Vandana MenonMark J Sarnak
Dec 13, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tetsuo ShojiYoshiki Nishizawa
May 29, 2004·Transplantation·Amgad E el-AgroudyMohamed A Ghoneim
Jun 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Wolfgang C WinkelmayerGere Sunder-Plassmann
Jun 18, 2004·Kidney International·Didier DuclouxJean-Marc Chalopin
Sep 29, 2004·American Journal of Nephrology·Esther A GonzálezKevin J Martin
Aug 2, 2005·Immunology Letters·Luciano AdoriniKenn C Daniel
Aug 24, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rutger M van ReeStephan J L Bakker
Oct 15, 2005·Hemodialysis International·Eric SeibertMartin K Kuhlmann
Nov 24, 2005·The Journal of Clinical Endocrinology and Metabolism·Kerstin QueringsJörg Reichrath
Mar 15, 2006·Transplantation·Brian J Nankivell, Jeremy R Chapman
Oct 5, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Jeroen AaltenAndries Hoitsma
Jan 31, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ron WaldDana C Miskulin
Feb 3, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Merav Cohen-LahavShraga Shany
Mar 17, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Wolfgang C WinkelmayerManuela Födinger
Apr 16, 2008·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Bettina EwersPeter Marckmann
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos

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Apr 16, 2008·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Bettina EwersPeter Marckmann

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