Impact of vitamin E supplement in standard laboratory animal diet on microvascular manifestation of ischemia/reperfusion injury

Free Radical Biology & Medicine
C WillyH A Lehr

Abstract

Aimed at improving animal fertility and health, diets for farm and laboratory animals have over the last few years been supplemented with increasing amounts of the antioxidant vitamin E. We now demonstrate by intravital microscopy that feeding hamsters with a vitamin E-supplemented "standard" rodent diet (60 ppm vitamin E) significantly reduces the microvascular manifestations of ischemia/reperfusion injury when compared to animals fed a nonsupplemented diet. Postischemic leukocyte adhesion to venular endothelium was reduced from 770 +/- 204 cells/mm2 at 24 h after reperfusion in control animals on the nonsupplemented diet to 403 +/- 105 cells/mm2 in animals on the "standard" rodent diet (means +/- SD, n = 7 animals per group, p < 0.01). Animals on the nonsupplemented diet showed a dramatic loss of capillary perfusion density until 7 days after reperfusion (to 21 +/- 13% of preischemic baseline values), whereas this loss was significantly attenuated (to 71 +/- 12% of preischemic values, p < 0.01) in animals on the "standard" rodent diet. No difference in the extent of reperfusion injury was seen between animals on the "standard" rodent diet and animals on diets with substantially higher vitamin E supplements (300 ppm-30,000 ppm...Continue Reading

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Citations

Nov 21, 1998·Free Radical Biology & Medicine·V A DyatlovD O Carpenter
Feb 3, 2000·Free Radical Biology & Medicine·C WillyU G Plappert
Aug 31, 2002·Journal of Cardiopulmonary Rehabilitation·John F Keaney, Joseph A Vita
Feb 19, 2000·Current Opinion in Lipidology·R Stocker
May 26, 2015·Brain Research Bulletin·Ruhollah KaramianAbdolrahman Sarihi
Aug 24, 1999·Archives of Physiology and Biochemistry·P VendittiC Agnisola
Jul 9, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Erwin M WiegmanRob P Coppes
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Mar 21, 2006·Surgery·Payam SalehiThomas A Churchill

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