PMID: 18727339Aug 30, 2008Paper

Impact of warm compresses on local injection-site reactions with self-administered glatiramer acetate

The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses
Helen JollyM A Oleen-Burkey

Abstract

Patients with multiple sclerosis (MS) report a number of adverse events related to immunomodulator injections, including local injection-site reactions (LISRs). Reactions characterized by pain, swelling, redness, or inflammation have been experienced by patients who self-inject glatiramer acetate, interferon beta-1b, or interferon beta-1a. Although these reactions rarely are serious, they can foster negative attitudes about self-injection and undermine a patient's commitment to treatment, especially in the early stages of therapy. This randomized crossover study of 50 patients who had initiated or restarted glatiramer acetate therapy within the 3 months before the study examined whether applying a warm compress to the injection site before self-injection would lower the incidence of LISRs compared with the patients' usual methods of injection preparation. Fewer LISRs were reported both 2 minutes and 5 minutes postinjection when warm compresses were used compared with the usual injection-site preparation (p < .001). Patients also were less bothered by LISRs when using warm compresses, as shown by mean scores on the Bothersome Scale (p = .02). Because warm compresses are easy to apply and appear to be at least modestly effective,...Continue Reading

References

Oct 24, 2001·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·C FraserT Vollmer
Nov 27, 2002·Neurology·H PanitchUNKNOWN University of British Columbia MS/MRI Research Group
Jan 25, 2003·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Jonathan A Drezner
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Aug 24, 2006·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Marijean Buhse

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Citations

Nov 26, 2010·Current Medical Research and Opinion·Jeffrey R CurtisKevin Hansbrough
Mar 1, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Deepak M W BalakH Bing Thio
Mar 2, 2010·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Gabriel PardoMerriKay Oleen-Burkey
Jan 7, 2011·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Amy Perrin Ross, Ben W Thrower
May 14, 2010·The Cochrane Database of Systematic Reviews·Loredana La MantiaRoberta Lovati
Mar 28, 2012·Expert Review of Neurotherapeutics·Kenneth P Johnson
Dec 22, 2017·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Jennifer M Woods
Aug 2, 2016·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Kazumasa Yokoyama, Nobutaka Hattori
Jun 22, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Adam J S McCartanRandall J Mrsny

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