Abstract
Obesity is a well-known risk factor for type 2 diabetes, but few data exist on the association between weight changes and diabetes risk in non-obese subjects. This study aimed to investigate the effect of weight changes on the incidence of type 2 diabetes in Korea, using 51,405 non-diabetic subjects. Individuals who developed type 2 diabetes were more likely to be older and male, to have high body mass index (BMI), blood pressure, fasting blood glucose, and total cholesterol, to be current smokers and frequent drinkers, to be hypertensive and hyperlipidemic, and to have a family history of diabetes, compared to those without type 2 diabetes. Compared with the consistently non-obese group, there was a higher hazard ratio for incident diabetes (95% confidence interval) in subjects becoming obese [1.49 (1.26-1.77)] and remaining obese [2.56 (2.34-2.81)] after adjustment for confounding factors. Decreased BMI was significantly associated with lower risks for incident diabetes and the trends were more evident in the non-obese group. However, overall there was no significant association of increased BMI with incident diabetes. In conclusion, weight loss was significantly associated with lower risk for diabetes both in non-obese and o...Continue Reading
References
May 1, 1994·Diabetes Care·S D LongJ F Caro
Apr 1, 1997·Diabetes Care·X R PanB V Howard
May 3, 2001·The New England Journal of Medicine·J TuomilehtoUNKNOWN Finnish Diabetes Prevention Study Group
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Jun 25, 2002·European Journal of Clinical Nutrition·K Ishikawa-TakataS Inoue
Jan 17, 2004·Lancet·UNKNOWN WHO Expert Consultation
Jun 12, 2004·American Journal of Epidemiology·Pauline Koh-BanerjeeEric B Rimm
Jan 15, 2005·Journal of Epidemiology and Community Health·S Goya WannametheeMary Walker
Jun 1, 2006·The Journal of Clinical Endocrinology and Metabolism·James B MeigsRalph B D'Agostino
Aug 24, 2006·The New England Journal of Medicine·Sun Ha JeeJonathan M Samet
Nov 14, 2006·Lancet·Jaana LindströmUNKNOWN Finnish Diabetes Prevention Study Group
Nov 14, 2006·Lancet·Kun-Ho YoonHo-Young Son
Mar 14, 2007·Diabetes Care·Gita D MishraAnnette J Dobson
Mar 31, 2007·Diabetes·John M LachinUNKNOWN DDK Research Group
Dec 13, 2007·JAMA : the Journal of the American Medical Association·Carole WilliJacques Cornuz
May 27, 2008·Lancet·Guangwei LiPeter H Bennett
Nov 3, 2009·Lancet·William C KnowlerDavid M Nathan
Nov 17, 2009·Diabetes Research and Clinical Practice·R K SimmonsS J Griffin
Jun 15, 2010·The International Journal of Biochemistry & Cell Biology·Aurore André, Marie-Paule Gonthier
Jul 16, 2010·Journal of Epidemiology and Community Health·Akiko NanriUNKNOWN Japan Public Health Center-based Prospective Study Group
May 28, 2011·Diabetes Care·Frank B Hu
Jul 7, 2011·PloS One·Paolo BoffettaJohn D Potter
Oct 30, 2013·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S KodamaH Sone
Sep 12, 2015·Diabetes Care·Gina S WeiCaroline S Fox
Dec 24, 2015·Diabetes Care·UNKNOWN American Diabetes Association
Jan 9, 2016·Stroke; a Journal of Cerebral Circulation·Tyler Hyungtaek RimSung Soo Kim
Sep 1, 2017·Journal of the American Heart Association·Han-Gil JeongSeung-Hoon Lee
Sep 25, 2017·The Journal of Clinical Endocrinology and Metabolism·Yang-Hyun KimUNKNOWN Taskforce Team of the Obesity Fact Sheet of the Korean Society for the Study of Obesity
Sep 28, 2017·BMJ Open·Sang Cheol SeongSeung-Lyeal Jeong
Nov 17, 2017·Diabetologia·Roy Taylor, Alison C Barnes
Citations
Nov 21, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·M KimJ H Lee
Jun 5, 2019·Gut and Liver·Jooyoung LeeJoo Sung Kim
Mar 20, 2020·Diabetes Care·Yang-Hyun KimYong-Gyu Park
Sep 3, 2020·BMJ Open Diabetes Research & Care·Laura Sares-JäskeSatu Männistö
Aug 14, 2019·The Journal of Clinical Endocrinology and Metabolism·Seung-Hwan LeeMee Kyoung Kim
Aug 24, 2019·Diabetes & Metabolism Journal·Yunjung Cho, Seung Hwan Lee
Nov 7, 2019·Current Diabetes Reviews·Ronald B Brown
Apr 4, 2021·Journal of Clinical Medicine·Eun Hui BaeSoo Wan Kim
Aug 5, 2021·Epidemiology·Michail KatsoulisHarry Hemingway