Impact of Y3+ -ions on the structure and phase behavior of phospholipid model membranes

Physical Chemistry Chemical Physics : PCCP
Steffen BornemannRoland Winter

Abstract

Trivalent yttrium cations are able to mimic the behavior of Ca2+ in many important biochemical processes, and their application in medicinal chemistry has increased in recent years. While the effect of mono- and divalent salts on lipid membranes has been studied extensively, the effect of trivalent cations, such as Y3+, on the structure and phase behavior of lipid bilayers is largely unknown. Here, we studied the effect of YCl3 on the structure, phase behavior and thermodynamic parameters of zwitterionic DPPC, 20% anionic DPPC/DPPG (80/20) and 10% anionic DOPC/DOPG/DPPC/DPPG/cholesterol (20/5/45/5/25) model biomembrane systems using Fourier-transform infrared spectroscopy, differential scanning calorimetry, Laurdan fluorescence spectroscopy, confocal fluorescence microscopy, zeta potential measurements and atomic force microscopy, covering a wide range of salt concentrations, temperature and pressure. Y3+ ions penetrate deep into the lipid headgroup region and are coordinated to the phosphate groups, resulting in a stronger lipid packing and partial dehydration of the headgroup region. Increasing Y3+ concentration leads to a pronounced increase of the gel-to-fluid phase transition temperature of the phospholipid bilayers, owing...Continue Reading

References

Jul 1, 1990·Biological Trace Element Research·R P PaivaC D Alonso
Apr 1, 1990·Journal of Bioenergetics and Biomembranes·D PapahadjopoulosN Düzgünes
Dec 1, 1988·Lipids·G B DíazJ J Gagliardino
Nov 27, 1987·Biochimica Et Biophysica Acta·J H IpsenM J Zuckermann
Mar 5, 1973·Biochemical and Biophysical Research Communications·S Ohnishi, T Ito
Jan 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·H Träuble, H Eibl
Jun 5, 1997·Nature·K Simons, E Ikonen
Jun 6, 2002·Chemistry and Physics of Lipids·Hans Binder, Olaf Zschörnig
Jul 9, 2002·Biochimica Et Biophysica Acta·Tomoki TanakaMasahito Yamazaki
Dec 18, 2002·Physical Review Letters·Sarah L Veatch, Sarah L Keller
Jun 1, 1960·Archives of Biochemistry and Biophysics·J OLIVARD
Sep 26, 2003·Biophysical Journal·Rodrigo F M de AlmeidaManuel Prieto
May 26, 2004·Archives of Biochemistry and Biophysics·Héctor A Lucero, Phillips W Robbins
Jun 17, 2004·Journal of the American Chemical Society·Sascha JanoschRoland Winter
Feb 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kirsten BaciaTeymuras Kurzchalia
Oct 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Christopher K HaluskaRumiana Dimova
Sep 13, 2007·The Journal of Biological Chemistry·Ana J García-SáezPetra Schwille
Nov 23, 1995·Nature·R Leberman, A K Soper
Jan 13, 2009·Journal of the American Chemical Society·Katrin WeiseRoland Winter
Jul 17, 2009·The Journal of Physical Chemistry. B·Zachary D SchultzIra W Levin
May 15, 2013·The Journal of Membrane Biology·Aneta D Petelska, Zbigniew A Figaszewski
Jan 20, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Hannah K Wayment-SteeleAngelika Kunze
Apr 4, 2016·Advances in Therapy·Joseph Ralph KalliniRobert J Lewandowski
Jun 21, 2016·Journal of Colloid and Interface Science·Ellen M AdamsHeather C Allen
Nov 18, 2016·Physical Chemistry Chemical Physics : PCCP·Ellen M AdamsHeather C Allen
Dec 3, 2016·Scientific Reports·Adéla MelcrováLukasz Cwiklik
Mar 1, 2017·Frontiers in Physiology·Hannah SteinVahid Sandoghdar
Jun 2, 2017·Physical Chemistry Chemical Physics : PCCP·Z T GraberT Baumgart
Oct 21, 2017·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Aneta D Petelska, Monika Naumowicz

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Citations

Aug 21, 2019·International Journal of Molecular Sciences·Charlotte PoschenriederJuan Barceló
Apr 28, 2020·Physical Chemistry Chemical Physics : PCCP·Steffen BornemannRoland Winter
May 5, 2020·Biophysical Journal·Mason L ValentineCarlos R Baiz
Jun 24, 2021·Physical Chemistry Chemical Physics : PCCP·Simon KrieglerRoland Winter
Jul 14, 2021·Physical Chemistry Chemical Physics : PCCP·Andresa MessiasThereza A Soares
Aug 14, 2020·Journal of the American Chemical Society·Vahid AdibniaXavier Banquy
Oct 9, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Simon KrieglerRoland Winter
Aug 5, 2020·Biochimica Et Biophysica Acta. Biomembranes·Marius HerzogRoland Winter

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Methods Mentioned

BETA
fluorescence spectroscopy
fluorescence microscopy
Dynamic light scattering
differential scanning calorimetry
atomic force microscopy
AFM
fluorescence

Software Mentioned

LaserSharp2000
Julabo Easy Temp

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