Impact on cytoprotective efficacy of intermediate interval between amifostine administration and radiotherapy: a retrospective analysis

International Journal of Radiation Oncology, Biology, Physics
Vassilios E KoulouliasL J Vlahos

Abstract

To evaluate the cytoprotective impact of the interval between amifostine administration and radiotherapy (RT). In a nonrandomized study, we reviewed the records of 177 patients with tumors localized in the pelvis (prostate, bladder, or gynecologic cancer), upper abdomen (pancreas, stomach, kidney), thorax (lung and breast cancer), head and neck (nasopharynx), soft tissue (sarcomas), and central nervous system. The patient records were stratified according to whether the patients had undergone RT either 25-40 min (Group 1, 96 subjects) or 10-15 min (Group 2, 81 subjects) after i.v. amifostine administration. The mean toxicity score was the mean value of recorded acute radiation toxicity. The mean interruption time was the mean value of the recorded interruption time due to radiation toxicity. A significantly reduced severity of symptoms related to oral (p = 0.023), esophageal (p = 0.05) and rectal (p = 0.015) mucosa was noted in Group 2. A statistically significant reduction in the mean toxicity score (p <0.001) and mean interruption time (p = 0.001) was observed in Group 2 vs. Group 1. In terms of the incidence of radiation-induced dermatitis and alopecia, multivariate logistic analysis revealed only the total dose (p = 0.018) ...Continue Reading

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Citations

Apr 6, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Rene-Jean BensadounDorothy Keefe
Oct 12, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ourania Nicolatou-GalitisUNKNOWN Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (
Mar 25, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·S B JensenUNKNOWN Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO)
Apr 26, 2006·Expert Opinion on Emerging Drugs·Joel B Epstein, Gary D Klasser
Nov 21, 2007·Dermatologic Clinics·T J FitzgeraldEdward Arous
Apr 4, 2006·Hematology/oncology Clinics of North America·C T ThomasH Elsaleh
Mar 24, 2012·International Journal of Radiation Oncology, Biology, Physics·Mary FengTheodore S Lawrence
Jul 31, 2012·International Journal of Otolaryngology·Jacqueline C JunnPatrick K Ha

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