Impact on Fertility After Failure of Restorative Proctocolectomy in Men and Women With Ulcerative Colitis: A 17-Year Cohort Study

Diseases of the Colon and Rectum
Frederik R PachlerSøren Laurberg

Abstract

Impact of restorative proctocolectomy failure on fertility has not been studied and is greatly relevant. The purpose of this study was to evaluate the impact of restorative proctocolectomy failure on birth rate in women and men, along with in vitro fertilization incidence and success. This was a retrospective registry-based cohort study over 17 years. Records for parenting a child were cross-linked with patient records. In women, in vitro fertilization records were cross-linked. All data were prospectively registered. Patients of fertile age with ulcerative colitis between 1994 and 2010 were identified in Danish national databases. Patients with restorative proctocolectomy and restorative proctocolectomy failure were identified as subgroups. Birth rate ratios and in vitro fertilization incidence and success were measured. We included 11,939 women and 13,569 men with ulcerative colitis. A total of 711 women and 730 men had restorative proctocolectomy; 114 women and 90 men had failure. Birth rate in women with failure was significantly reduced compared with women without (birth rate ratio = 0.50 (95% CI, 0.29-0.82)). In men with failure, birth rate tended to be lower compared with men without (birth rate ratio = 0.74 (95% CI, 0.5...Continue Reading

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Citations

Apr 15, 2021·Diseases of the Colon and Rectum·Stefan D HolubarUNKNOWN Prepared on behalf of the Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons
May 29, 2021·Therapeutic Advances in Gastroenterology·Robyn LaubeRupert W Leong
Oct 26, 2021·The American Journal of Gastroenterology·Robyn LaubeRupert W Leong

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