Impacts of a new transcription factor family: mammalian GCM proteins in health and disease

The Journal of Cell Biology
Said Hashemolhosseini, Michael Wegner

Abstract

GCM proteins constitute a small transcription factor family with a DNA-binding domain exhibiting a novel fold composed of two subdomains rigidly held together by coordination of one of two structural zinc cations. In all known cases, GCM proteins exert the role of master regulators: the prototypical family member determines gliogenesis in Drosophila melanogaster, whereas mammalian GCM proteins orchestrate divergent aspects of development and physiology in placenta, kidney, thymus, and parathyroid gland. Recent data point to an involvement of GCM proteins in different pathological contexts, such as preeclampsia, hyper- or hypoparathyroidism, and parathyroid gland tumors.

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Citations

Oct 27, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Reiner StrickPamela L Strissel
May 13, 2005·Biology of Reproduction·You-Hong Cheng, Stuart Handwerger
Oct 31, 2008·Biology of Reproduction·Amanda M de MestreDouglas F Antczak
Apr 22, 2009·Development, Growth & Differentiation·Yoshihiko Umesono, Kiyokazu Agata
Jul 11, 2006·Annual Review of Cell and Developmental Biology·Volker Hartenstein
Apr 17, 2014·Transgenic Research·Ziqiang YuanMichael A Levine
May 16, 2006·Medical Hypotheses·Heinrich Sticht, Said Hashemolhosseini
Apr 7, 2010·Leukemia Research·Yi SunYong-Tang Zheng
Aug 24, 2013·Cell Cycle·Pierre B Cattenoz, Angela Giangrande
Jul 31, 2012·Developmental Biology·Haian MaoMargaret S Ho
Jan 3, 2008·The Journal of Biological Chemistry·Steffen Wolfgang SchubertSaid Hashemolhosseini
Mar 27, 2019·Journal of Human Genetics·Khushdeep BandeshDwaipayan Bharadwaj

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