Impacts of Co-Existing Chronic Rhinosinusitis on Disease Severity and Risks of Exacerbations in Chinese Adults with Bronchiectasis

PloS One
Wei-jie GuanNan-Shan Zhong

Abstract

Mounting evidence supports the notion of "one airway, one disease." To determine whether chronic rhinosinusitis (CRS) poses adverse impacts on Chinese adults with bronchiectasis. We enrolled 148 consecutive adults with clinically stable bronchiectasis. CRS diagnosed based on the 2012 EP3OS criteria. We systematically evaluated the bronchiectasis etiology, radiology, lung function, sputum bacteriology, airway inflammatory biomarkers, Bronchiectasis Severity Index, cough sensitivity and healthcare resource utilization. All patients were prospectively followed-up for 1 year to examine the frequency of bronchiectasis exacerbations (BEs). Forty-seven patients (31.8%) were diagnosed as having CRS. Bronchiectasis etiologies did not vary statistically between CRS and no-CRS group. There was a trend towards non-statistically higher Bronchiectasis Severity Index [6.4±3.4 vs. 5.0(6.0), P = 0.19], a higher proportion of patients with BEs needing hospitalization before enrollment (48.9% vs. 29.7%, P = 0.13), poorer FVC [78.2±19.8% vs. 82.2(16.8)%, P = 0.54] and FEV1 [68.2±24.8% vs. 74.8(21.2)%, P = 0.29], a higher prevalence of Pseudomonas aeruginosa isolated (36.2% vs. 26.7%, P = 0.27) or colonized in sputum (36.2% vs. 21.8%, P = 0.12) and...Continue Reading

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Citations

Jan 24, 2016·Current Allergy and Asthma Reports·Derrick TintElina Toskala
Jan 25, 2018·ERJ Open Research·Michal ShteinbergYochai Adir
Jan 27, 2018·The European Respiratory Journal·Sanjay H Chotirmall, James D Chalmers
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Apr 16, 2020·Frontiers in Cell and Developmental Biology·Anu Laulajainen-HongistoRobert Kern
Oct 15, 2021·Immunity, Inflammation and Disease·Annemarie L LeeMark Hew
May 29, 2020·Respiration; International Review of Thoracic Diseases·Claudia CrimiNunzio Crimi

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS
Graphpad Prism

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