Impacts of cytosolic phospholipase A2, 15-prostaglandin dehydrogenase, and cyclooxygenase-2 expressions on tumor progression in colorectal cancer.

Yonsei Medical Journal
Sung Chul LimKyung Jong Kim

Abstract

In addition to cyclooxygenase-2 (COX-2) which is related to prostaglandin E2 synthesis, other enzymes such as cytosolic phospholipase A2 (cPLA2), microsomal prostaglandin E2 synthase-1 (mPGES-1), and 15-prostaglandin dehydrogenase (15-PGDH) have been suggested to be related to carcinogenesis of colorectal cancer (CRC). The aim of this study was to investigate the roles of cPLA2, COX-2, mPGES-1, and 15-PGDH in tumor progression. cPLA2, COX-2, mPGES-1, 15-PGDH, and vascular endothelial growth factor (VEGF) expressions were immunohistochemically examined in 89 CRC, and their expressions were compared with each other or clinicopathologic parameters as well as VEGF as tumor progression parameters. cPLA2 was expressed in 54.5%, COX-2 in 80.5%, mPGES-1 in 96.4%, 15-PGDH in 46.1%, and VEGF in 65.9%. The expression of cPLA2 correlated with VEGF expression. COX-2 expression was correlated with the depth of invasion, tumor stage, cPLA2, and VEGF expressions. Moreover, VEGF revealed the highest expression in the tissues positive for both cPLA2 and COX-2. Furthermore, 15-PGDH expression was inversely correlated with VEGF expression. The present study demonstrates that cPLA2 and mPGES-1, in addition to COX-2, are constitutively overexpressed...Continue Reading

References

Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Jul 15, 1985·International Journal of Cancer. Journal International Du Cancer·P BoyleM Smans
Jan 1, 1986·Annual Review of Biochemistry·P NeedlemanJ B Lefkowith
Oct 1, 1995·Journal of Lipid Mediators and Cell Signalling·C M Ensor, H H Tai
Sep 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A S SoydanA Bennett
Jul 4, 1997·The Journal of Biological Chemistry·C C Leslie
Apr 10, 1999·The Journal of Biological Chemistry·K SubbaramaiahA J Dannenberg
May 20, 1999·Annual Review of Pharmacology and Toxicology·J BalsindeE A Dennis
Jan 12, 2000·Oncogene·C S WilliamsR N DuBois
Nov 15, 2000·Critical Reviews in Clinical Laboratory Sciences·E Fosslien
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·K H HongE S Lander
Jan 12, 2002·Diseases of the Colon and Rectum·Takeyoshi YamauchiMasaki Kitajima
May 11, 2002·The American Journal of Gastroenterology·Hong Zhang, Xiao-Feng Sun
Feb 1, 2003·Trends in Pharmacological Sciences·Kotha Subbaramaiah, Andrew J Dannenberg
Feb 20, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Dominique WendumJean-François Fléjou
Mar 11, 2003·The Journal of Biological Chemistry·Daisuke KameiIchiro Kudo
Jul 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Catherine E TrebinoLaurent P Audoly
Aug 21, 2003·Drug Discovery Today·Jonathan P Laye, Jason H Gill
Oct 2, 2003·International Journal of Cancer. Journal International Du Cancer·Bastiaan P van ReesAri Ristimäki
Nov 16, 2004·The Journal of Biological Chemistry·Michael G BacklundRaymond N DuBois
Dec 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Min YanSanford D Markowitz
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Labile Togba SoumaoroKenichi Sugihara
Mar 25, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mei DongDaniel W Rosenberg
Apr 5, 2005·Cancer Research·Jillian N M IlsleyDaniel W Rosenberg
Jul 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Richard FuxPeter Fritz
Dec 15, 2005·The Journal of Pathology·Sanjana MehrotraSunil Badve
Aug 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Seung-Jae MyungSanford D Markowitz
Aug 4, 2006·Cancer Research·Ido WolfH Phillip Koeffler
Nov 23, 2006·The British Journal of Surgery·A D ThorntonK Chester
Jun 28, 2007·Yonsei Medical Journal·Sung-Chul LimYoung-Don Min
May 3, 2008·Cancer Research·Masako NakanishiDaniel W Rosenberg
Apr 1, 2002·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jong Myon BaeJae Gahb Park

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Citations

Feb 24, 2012·International Journal of Colorectal Disease·Yunxian YuKun Chen
May 4, 2012·World Journal of Gastroenterology : WJG·Jaudah Al-MaghrabiMahmoud Al-Ahwal
Oct 26, 2011·Future Medicinal Chemistry·Hui-Hua Chang, Emmanuelle J Meuillet
May 9, 2013·International Journal of Hepatology·Kelly J LafaroDavid K Imagawa
Jun 19, 2013·Bioelectrochemistry·S C B OliveiraA M Oliveira-Brett
Jun 30, 2012·The International Journal of Biochemistry & Cell Biology·Pratima TripathiAyyalusamy Ramamoorthy
Nov 9, 2011·Journal of the Korean Surgical Society·Young Sun YooKyung Jong Kim
Nov 28, 2012·Journal of the Korean Society of Coloproctology·Pil Sung KangKyung Jong Kim
Aug 26, 2015·Molecular and Cellular Biology·Said Movahedi NainiJoseph V Bonventre
May 22, 2019·International Journal of Molecular Sciences·Nor Isnida IsmailRakesh Naidu
Jul 16, 2014·Medicinal Research Reviews·Malkeet Singh BahiaPragati Silakari
Aug 15, 2018·Veterinary Sciences·Walaa Hamed Shaker NasryChelsea K Martin
Jan 11, 2018·Nanomedicine : Nanotechnology, Biology, and Medicine·Raghavendra GowdaGavin P Robertson

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